Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3890036..3890693 Replicon chromosome
Accession NZ_CP072961
Organism Enterobacter sp. MGH 14

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag IBG17_RS18810 Protein ID WP_022649305.1
Coordinates 3890036..3890446 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag IBG17_RS18815 Protein ID WP_003863437.1
Coordinates 3890427..3890693 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG17_RS18790 3886034..3887767 - 1734 WP_022651808.1 single-stranded-DNA-specific exonuclease RecJ -
IBG17_RS18795 3887773..3888486 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IBG17_RS18800 3888515..3889411 - 897 WP_022651809.1 site-specific tyrosine recombinase XerD -
IBG17_RS18805 3889513..3890034 + 522 WP_003863440.1 flavodoxin FldB -
IBG17_RS18810 3890036..3890446 - 411 WP_022649305.1 protein YgfX Toxin
IBG17_RS18815 3890427..3890693 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
IBG17_RS18820 3890988..3891968 + 981 WP_003863435.1 tRNA-modifying protein YgfZ -
IBG17_RS18825 3892054..3892713 - 660 WP_003863433.1 hemolysin III family protein -
IBG17_RS18830 3892980..3893711 + 732 WP_003863431.1 MurR/RpiR family transcriptional regulator -
IBG17_RS18835 3893828..3895261 + 1434 WP_022651811.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T199307 WP_022649305.1 NZ_CP072961:c3890446-3890036 [Enterobacter sp. MGH 14]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T199307 NZ_CP097291:c3798599-3798393 [Providencia sp. PROV188]
ATGCATGACCTGAAAGATATTCGAGCAAAAACAAAAATACAGATAAGAATTCGGCGTTTGAAGCAAGGCAATTTTGGTGA
TGTTGAATCAATAGGTGATGGTTTTTCTGAATTAAAAATACATGAAGGGAAAGGATATCGCGTTTATTTAAGAAAGATTG
ATAATACAATCGTATTGTTAATCAGCGGTGGTGATAAATCGACGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT199307 WP_003863437.1 NZ_CP072961:c3890693-3890427 [Enterobacter sp. MGH 14]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT199307 NZ_CP097291:c3798339-3798052 [Providencia sp. PROV188]
ATGAATATTAAAATAAAAGAGTATGACATTGCTGAGCACTTAACGAACGAAGAAGAAATTCAGCTGTATCTTAATGAAAT
ATTAGAAGAAGGCGATACGGCACTCATTCTTGCGGCATTAGGCGATATTGCGAGAGCGAGAAATATGACCCAATTAGCAA
AGGAAGTAGGAATGAGCCGAGAAGGGCTATATAAGGCACTATCTGGTGAAGGTAACCCTGCATTTACCACTATCTTGAAG
ATAGTTCATTCACTAGGACTAAAGTTGCAATTTAAGAGCGCAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References