Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2350200..2350939 Replicon chromosome
Accession NZ_CP072961
Organism Enterobacter sp. MGH 14

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag IBG17_RS11525 Protein ID WP_003857133.1
Coordinates 2350200..2350685 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag IBG17_RS11530 Protein ID WP_003857131.1
Coordinates 2350673..2350939 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG17_RS11505 2346353..2347111 - 759 WP_022651197.1 trans-aconitate 2-methyltransferase -
IBG17_RS11510 2347196..2347780 - 585 WP_022651198.1 NUDIX hydrolase -
IBG17_RS11515 2347867..2348625 + 759 WP_003857136.1 DeoR/GlpR family DNA-binding transcription regulator -
IBG17_RS11520 2348730..2350022 + 1293 WP_022651199.1 glycosyl hydrolase family 28 protein -
IBG17_RS11525 2350200..2350685 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
IBG17_RS11530 2350673..2350939 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
IBG17_RS11535 2351003..2351932 - 930 WP_022651200.1 LysR family transcriptional regulator -
IBG17_RS11540 2352062..2353450 + 1389 WP_032645625.1 MFS transporter -
IBG17_RS11545 2353472..2354467 - 996 WP_003857125.1 DUF2891 domain-containing protein -
IBG17_RS11550 2354477..2355463 - 987 WP_022651202.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T199297 WP_003857133.1 NZ_CP072961:c2350685-2350200 [Enterobacter sp. MGH 14]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T199297 NZ_CP097289:1273774-1274196 [Streptomyces durmitorensis]
CTGAAGGCTGACAGGCCGGACCTGGCCCCCGAAGTGCTCGACAGGACACGGCGGCTGATGAAGGCAGCGGTACGGGACTG
TCTCGTGAAGGGACACGAGCCGCTCATCGACATACTGGAGCTCCCGGACAAGGACGACCGCCACGTTCTGGCTGCGGCGA
TCCGCGCCAAAGCCCAAGTGATTGTGACGTTCAACCTCAAAGATTTCCCCGCGGAAGCCTTGGCGCCATGGGACGTAGAA
GCCGTCCACCCGGACGCATTCCTCGAAGCGCAGATAGACCTGGCGCCGGAGATCGTCTACGGAGAGATCCAACGTATCGC
CGACAGTTGGAAGAACCCACCCGGCACGGTTGCCGACGTGATCGAGCGACTCGACAGGAACCGTCTTGTTTCTTCCGCAG
CGGCCCTGAGGGCGCTCACCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT199297 WP_003857131.1 NZ_CP072961:c2350939-2350673 [Enterobacter sp. MGH 14]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT199297 NZ_CP097289:1273173-1273634 [Streptomyces durmitorensis]
GTGACGAAGACAGACTTCAGGCCCGTGAAGCTCCCGCCCGAGAAGACCGCCACAGCGAACCGTGCCCTCACCCGTGTCCG
CGGCTACCTTGCCGAACATCCCGACCTCGGACAGATTGCCGTCAAGCCGCTCGACGACAGAGAGCCTGAGCCCCTCACAC
TGCCCCGTGAGGCCGTCGAGCTCCTCGCCGGTCTCCTCGCTCACCTCGGGGCAGGCCGAGGCGTGTCCATCGTCCCCAGC
ACCGCGGAGCTCACTACCCAGCAAGCGGCAGACATCCTCAACGTTTCCCGGCCCTTCCTCATCGGCCTCCTGGACGCAGG
CGAAATCGAGTGCCGTCTAGTCGGAACGCACCGCAGGATCACGGCGTCCTCGCTCATGGAGTACAAGCAAGCAGACGACC
GGCGCCGTCGTGAAGCAGCAGACGAGCTCACTCAGCTCGGCCAGGAGATGGGAATGATGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References