Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1095330..1095950 Replicon chromosome
Accession NZ_CP072961
Organism Enterobacter sp. MGH 14

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag IBG17_RS05090 Protein ID WP_015571250.1
Coordinates 1095330..1095548 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag IBG17_RS05095 Protein ID WP_006809850.1
Coordinates 1095576..1095950 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG17_RS05060 1091342..1091602 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
IBG17_RS05065 1091605..1091745 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
IBG17_RS05070 1091742..1092452 - 711 WP_022650493.1 GNAT family protein -
IBG17_RS05075 1092554..1094014 + 1461 WP_022650494.1 PLP-dependent aminotransferase family protein -
IBG17_RS05080 1093986..1094453 - 468 WP_022650495.1 YlaC family protein -
IBG17_RS05085 1094570..1095121 - 552 WP_022650496.1 maltose O-acetyltransferase -
IBG17_RS05090 1095330..1095548 - 219 WP_015571250.1 HHA domain-containing protein Toxin
IBG17_RS05095 1095576..1095950 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
IBG17_RS05100 1096461..1099607 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
IBG17_RS05105 1099630..1100823 - 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T199295 WP_015571250.1 NZ_CP072961:c1095548-1095330 [Enterobacter sp. MGH 14]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T199295 NZ_CP097287:30505-30807 [Pseudomonas viridiflava]
ATGAAAACGATTATCCAAACCGCCACTTACATGACTTGGGAACGCAAACTGCGTGACAAGAAGGCCAAACTGATTATCGC
GGCGCGGGTGTTGCGAGTTGCCCACGGCTTGCTCGGTGACGTGCAGCCAGTTGGTCAAGGCGTCAGTGAGTTGCGAATTC
ATCATGGTCCCGGCTACCGGGTGTATTTCCAGCAGCGCGGCGATCAGCTGGTCCTATTGCTCTGCGGTGGGGATAAAAGC
AGTCAAGCGCGGGACATTGAGACCGCTAAAACTCTGGCAAGCCAGTGGAGTGAAGACGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT199295 WP_006809850.1 NZ_CP072961:c1095950-1095576 [Enterobacter sp. MGH 14]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT199295 NZ_CP097287:30804-31100 [Pseudomonas viridiflava]
ATGAAAGAACCAATTTACGAATACGACCCAGCGGAATTACTCACCGATGCCGAATCTATCGCCATTTTCATGGCTGATGC
TTTTGAATCGGGCGATGCATCATTCATCGCGCAGGCGCTGAGCGTGGTAGCTCGCGCCAAAGGCATGACCGCAATTGCAA
AAGAGGCAGGCGTTACCCGCGCACACCTCTACCAACTGAAAAACGGCAACCCCACTTTGAAAACCATGATCGGGGTCATG
CGTGCGGTCGGTCTGGACATGACAGCAAAACAACACGTCGATGTAGCCCACGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References