Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 124006..124649 Replicon plasmid unnamed1
Accession NZ_CP072954
Organism Enterobacter sp. MGH 3

Toxin (Protein)


Gene name vagD Uniprot ID A0A6C0NE46
Locus tag IBG19_RS24645 Protein ID WP_008322233.1
Coordinates 124006..124422 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag IBG19_RS24650 Protein ID WP_001261276.1
Coordinates 124419..124649 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG19_RS24625 120076..121095 + 1020 WP_004113181.1 ribose ABC transporter permease -
IBG19_RS24630 121173..122543 + 1371 WP_008322237.1 hypothetical protein -
IBG19_RS24635 122540..123460 + 921 WP_008322235.1 carbohydrate kinase -
IBG19_RS24645 124006..124422 - 417 WP_008322233.1 type II toxin-antitoxin system VapC family toxin Toxin
IBG19_RS24650 124419..124649 - 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IBG19_RS24655 124902..125924 - 1023 WP_008322227.1 helicase UvrD -
IBG19_RS24660 126010..126714 + 705 WP_001067848.1 IS6-like element IS26 family transposase -
IBG19_RS24665 127117..127473 + 357 WP_000215515.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(D) / sul1 / qacE / ere(A) / aac(6')-IIc / sul2 / blaTEM-1A / aph(3')-Ia - 1..241263 241263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15054.58 Da        Isoelectric Point: 9.2957

>T199292 WP_008322233.1 NZ_CP072954:c124422-124006 [Enterobacter sp. MGH 3]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAASAVLVTNNVREFARVPGLMLEDWVK

Download         Length: 417 bp

>T199292 NZ_CP097286:c5403887-5403669 [Pseudomonas viridiflava]
GTGACGACAGTTGAATGGAGTTCTTGGGCCAGGCAGGACTTGCTGGCCATCATCGATTACATCTCTGATGACAACGTGAC
GGCGGCGCAAGAAATGAAGGACACCATCGAAAGCCGGGTGGCTAATCTTCCTTTGCACCCAAGGCTTTATAAGGAAGGCC
GTGAGCCGGGGACCCGCGAGATGGTCGTACATCCAAATTACATCGTTATCTACAAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT199292 WP_001261276.1 NZ_CP072954:c124649-124419 [Enterobacter sp. MGH 3]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT199292 NZ_CP097286:c5404173-5403874 [Pseudomonas viridiflava]
ATGGCAACGCACACATCCATGCTGCATGTACGTATAGATAACGATCTCAAAACACAGGCGACCGAAACGCTAGCAAAATT
CGGCCTTACCGTGTCGGATGCGGTCAGGATCCTGCTGACCCGTGTCGCCAGGGAAGGTGCCCTGCCTGTCGGGTTCACCA
GCGATGCCGAAGCGTACGACAAGTGGTTTCGGGCAAAGGTAAAAGAAGCCATGGATGACACGCAACCGTCCATAACTCAC
GAGCAGATGATGGCAGAAGCTCAGCAGCTAATAGACAGGAAGCGCCGTGACGACAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C0NE46

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References