Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3132759..3134542 Replicon chromosome
Accession NZ_CP072953
Organism Enterobacter sp. MGH 3

Toxin (Protein)


Gene name hipA Uniprot ID A0A8B5ZXW9
Locus tag IBG19_RS15220 Protein ID WP_022651516.1
Coordinates 3132759..3134108 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A837FFV9
Locus tag IBG19_RS15225 Protein ID WP_003859317.1
Coordinates 3134105..3134542 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG19_RS15195 3128582..3129517 - 936 WP_003859306.1 tRNA dihydrouridine(16) synthase DusC -
IBG19_RS15200 3129686..3130081 + 396 WP_003859308.1 CidA/LrgA family protein -
IBG19_RS15205 3130078..3130773 + 696 WP_003859310.1 CidB/LrgB family autolysis modulator -
IBG19_RS15210 3130902..3131786 + 885 WP_022651515.1 cytidine deaminase -
IBG19_RS15215 3131914..3132624 + 711 WP_003859314.1 outer membrane permeability protein SanA -
IBG19_RS15220 3132759..3134108 + 1350 WP_022651516.1 HipA domain-containing protein Toxin
IBG19_RS15225 3134105..3134542 + 438 WP_003859317.1 helix-turn-helix transcriptional regulator Antitoxin
IBG19_RS15230 3134581..3135591 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
IBG19_RS15235 3135607..3137127 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
IBG19_RS15240 3137207..3138205 - 999 WP_003859322.1 galactose/glucose ABC transporter substrate-binding protein MglB -
IBG19_RS15245 3138501..3139523 - 1023 WP_003859324.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51151.85 Da        Isoelectric Point: 4.7049

>T199289 WP_022651516.1 NZ_CP072953:3132759-3134108 [Enterobacter sp. MGH 3]
METLTVQAYLNETWTDIALIKYPGSEKKDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

>T199289 NZ_CP097266:1885199-1885612 [Acidovorax sp. NCPPB 3859]
ATGGCCGCGGATAAGGGCAAGGTATTCCTCGACAGCAACGTGGTGCTCTACCTGCTGTCCGAGAATGCAGCGAAGGCAGA
CAGCGCCGAGGCCCTACTGCAGCGTCGCCCCGTCATCAGCGTACAGGTACTCAACGAGGTCACTCACGTCTGCGTGCGCA
AGCTGAAGATGGGGTGGAGCGAGGTGGGGCAGTTCCTGGCGCTGGTGAGAGGGTTCTGCAGTATTGTTCCGCTCACGGTC
GAGGTGCATGACCGGGCCCGCCAGCTGGCCGAGCGGCATCAGTTGTCGTTCTACGACGCATGCATCGTGGCGGCGGCCGC
AGCCGAAGGCTGCCAGACGCTCTACTCCGAAGACATGCACCATGGCCTCATCATCGAAGAGAGCCTGTCGATTCGTAACC
CGTTCAACGTGTGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16185.64 Da        Isoelectric Point: 10.5154

>AT199289 WP_003859317.1 NZ_CP072953:3134105-3134542 [Enterobacter sp. MGH 3]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp

>AT199289 NZ_CP097266:1884979-1885212 [Acidovorax sp. NCPPB 3859]
ATGCAAGTCGCGAAGTGGGGTAACAGTCTGGCCGTCCGCCTGCCGACGAGTCTGGTGGAGGCGCTCGAACTGAGGGAGGG
AGACGACATCGAGATCGTCGTGGACGCTCCCCGGCTGTTCGCGGTGCGCAAGAAGCCCGGCGCGGAGGCCATGCTGGAGC
GGCTTCGCACCTTCCGCGGCAAGCTGCCGGCGGACTTCAAGTTCAACCGGGATGAGGCCAATGGCCGCGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5ZXW9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FFV9

References