Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1095331..1095951 Replicon chromosome
Accession NZ_CP072953
Organism Enterobacter sp. MGH 3

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag IBG19_RS05090 Protein ID WP_015571250.1
Coordinates 1095331..1095549 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag IBG19_RS05095 Protein ID WP_006809850.1
Coordinates 1095577..1095951 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG19_RS05060 1091343..1091603 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
IBG19_RS05065 1091606..1091746 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
IBG19_RS05070 1091743..1092453 - 711 WP_022650493.1 GNAT family protein -
IBG19_RS05075 1092555..1094015 + 1461 WP_022650494.1 PLP-dependent aminotransferase family protein -
IBG19_RS05080 1093987..1094454 - 468 WP_022650495.1 YlaC family protein -
IBG19_RS05085 1094571..1095122 - 552 WP_022650496.1 maltose O-acetyltransferase -
IBG19_RS05090 1095331..1095549 - 219 WP_015571250.1 HHA domain-containing protein Toxin
IBG19_RS05095 1095577..1095951 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
IBG19_RS05100 1096462..1099608 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
IBG19_RS05105 1099631..1100824 - 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T199278 WP_015571250.1 NZ_CP072953:c1095549-1095331 [Enterobacter sp. MGH 3]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T199278 NZ_CP097262:c4031664-4031356 [Salmonella enterica subsp. enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT199278 WP_006809850.1 NZ_CP072953:c1095951-1095577 [Enterobacter sp. MGH 3]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT199278 NZ_CP097262:c4031906-4031667 [Salmonella enterica subsp. enterica]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References