199270

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4731232..4731902 Replicon chromosome
Accession NZ_CP072949
Organism Klebsiella pneumoniae MGH 39

Toxin (Protein)


Gene name ypjF Uniprot ID A0A483GLH7
Locus tag IBD60_RS23105 Protein ID WP_023301398.1
Coordinates 4731232..4731564 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A483GII7
Locus tag IBD60_RS23110 Protein ID WP_023301397.1
Coordinates 4731585..4731902 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBD60_RS23080 4726457..4727129 + 673 Protein_4542 DUF4400 domain-containing protein -
IBD60_RS23085 4727140..4728024 + 885 WP_004192285.1 RES domain-containing protein -
IBD60_RS23090 4728223..4728411 - 189 Protein_4544 transposase -
IBD60_RS23095 4728428..4729539 - 1112 Protein_4545 IS3 family transposase -
IBD60_RS23100 4729938..4730798 - 861 WP_023301399.1 hypothetical protein -
IBD60_RS23105 4731232..4731564 - 333 WP_023301398.1 TA system toxin CbtA family protein Toxin
IBD60_RS23110 4731585..4731902 - 318 WP_023301397.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IBD60_RS23115 4731921..4732142 - 222 WP_023301396.1 DUF987 domain-containing protein -
IBD60_RS23120 4732151..4732633 - 483 WP_023301395.1 RadC family protein -
IBD60_RS23125 4732642..4733100 - 459 WP_023301394.1 antirestriction protein -
IBD60_RS23130 4733186..4733422 - 237 WP_032446575.1 DUF905 domain-containing protein -
IBD60_RS23135 4733500..4733910 - 411 WP_023301393.1 hypothetical protein -
IBD60_RS23140 4733977..4734414 - 438 WP_023301392.1 hypothetical protein -
IBD60_RS23145 4734456..4734992 - 537 WP_023301391.1 DUF4339 domain-containing protein -
IBD60_RS23150 4735018..4735728 - 711 WP_023301390.1 DeoR family transcriptional regulator -
IBD60_RS23155 4735937..4736761 - 825 WP_023301389.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-101)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12610.65 Da        Isoelectric Point: 5.6692

>T199270 WP_023301398.1 NZ_CP072949:c4731564-4731232 [Klebsiella pneumoniae MGH 39]
MKTLPATTPQTAKLCLTSADTWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIPLADAVNFLVDKYALVRIDRRGL
SWQEQSSYLRLVDTQRTIKVIELWLFGVMM

Download         Length: 333 bp

>T199270 NZ_CP097262:825279-825692 [Salmonella enterica subsp. enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11785.37 Da        Isoelectric Point: 6.6277

>AT199270 WP_023301397.1 NZ_CP072949:c4731902-4731585 [Klebsiella pneumoniae MGH 39]
MSNITWGLQRDITPCLGSRLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSSGYVYIAVYLTQR

Download         Length: 318 bp

>AT199270 NZ_CP097262:825032-825298 [Salmonella enterica subsp. enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A483GII7

References