199256

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 802432..803089 Replicon chromosome
Accession NZ_CP072949
Organism Klebsiella pneumoniae MGH 39

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IBD60_RS03980 Protein ID WP_002916310.1
Coordinates 802679..803089 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IBD60_RS03975 Protein ID WP_002916312.1
Coordinates 802432..802698 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBD60_RS03950 797588..799021 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
IBD60_RS03955 799140..799868 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IBD60_RS03960 799918..800229 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
IBD60_RS03965 800393..801052 + 660 WP_002916317.1 hemolysin III family protein -
IBD60_RS03970 801203..802186 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
IBD60_RS03975 802432..802698 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IBD60_RS03980 802679..803089 + 411 WP_002916310.1 protein YgfX Toxin
IBD60_RS03985 803096..803617 - 522 WP_002916308.1 flavodoxin FldB -
IBD60_RS03990 803718..804614 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IBD60_RS03995 804637..805350 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IBD60_RS04000 805356..807089 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T199256 WP_002916310.1 NZ_CP072949:802679-803089 [Klebsiella pneumoniae MGH 39]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T199256 NZ_CP097255:c3781259-3780849 [Enterobacter bugandensis]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGGCTGGTTGCGGC
CATCGTTTTACTCATGCCGTGGCCGCTCAGCTATACGCCGCTGTGGCTGCTATTACTTTCGTTTGTTGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAACGCGCGTCAGGGCGAGATTAAGCTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTCGGTGTACCCTGGATGCTTAACGCCGGGATGATGTTACGGTTACGCAAAGTGGGGGGCGGACGTTG
CCAGCACCTGTGGCTGGCGGCGGACAGTATGGACGCATCAGAATGGCGGGATCTGCGCCGGATGTTGCTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT199256 WP_002916312.1 NZ_CP072949:802432-802698 [Klebsiella pneumoniae MGH 39]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT199256 NZ_CP097255:c3781506-3781240 [Enterobacter bugandensis]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGTCGCGGAATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTACGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References