Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 279643..280169 Replicon plasmid unnamed1
Accession NZ_CP072946
Organism Enterobacter sp. MGH 7

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag IAU58_RS25060 Protein ID WP_000323025.1
Coordinates 279643..279930 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag IAU58_RS25065 Protein ID WP_000534858.1
Coordinates 279930..280169 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAU58_RS25005 274978..275361 + 384 WP_050596975.1 hypothetical protein -
IAU58_RS25010 275372..275626 + 255 WP_032610479.1 hypothetical protein -
IAU58_RS25015 275626..276042 + 417 WP_032610480.1 hypothetical protein -
IAU58_RS26055 276042..276173 + 132 WP_255344485.1 hypothetical protein -
IAU58_RS25020 276160..276441 + 282 WP_032610524.1 hypothetical protein -
IAU58_RS25025 276627..277181 + 555 WP_015063016.1 hypothetical protein -
IAU58_RS25030 277241..277489 + 249 WP_050596976.1 hypothetical protein -
IAU58_RS25035 277614..277946 + 333 WP_032610481.1 DUF5417 domain-containing protein -
IAU58_RS25040 277991..278560 + 570 WP_032610483.1 hypothetical protein -
IAU58_RS25045 278584..278934 + 351 WP_032610485.1 hypothetical protein -
IAU58_RS25050 278974..279180 + 207 WP_044255297.1 hypothetical protein -
IAU58_RS25055 279414..279572 - 159 WP_064758473.1 type I toxin-antitoxin system Hok family toxin -
IAU58_RS25060 279643..279930 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
IAU58_RS25065 279930..280169 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
IAU58_RS26000 280194..280298 + 105 Protein_299 hypothetical protein -
IAU58_RS25070 280432..281355 - 924 WP_032610488.1 cation diffusion facilitator family transporter -
IAU58_RS25075 281555..282127 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
IAU58_RS25080 282603..283841 - 1239 WP_003030308.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaSHV-30 / blaKPC-3 / aac(6')-Ib / ant(3'')-Ia / blaOXA-9 / blaTEM-1A - 1..417086 417086


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T199252 WP_000323025.1 NZ_CP072946:c279930-279643 [Enterobacter sp. MGH 7]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T199252 NZ_CP097255:c1103626-1103408 [Enterobacter bugandensis]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACCCTTGAACGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGCCTTGCAGAGC
TAACGATGAATAAGCTGTATGACAAAATCCCTACTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT199252 WP_000534858.1 NZ_CP072946:c280169-279930 [Enterobacter sp. MGH 7]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT199252 NZ_CP097255:c1104028-1103654 [Enterobacter bugandensis]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGCAACCATGGCTGGGTAAATGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCTACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACACTCAGGATTTGCAAAAATGGCGTAAATCGGGAAACCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References