Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3961755..3962412 Replicon chromosome
Accession NZ_CP072945
Organism Enterobacter sp. MGH 7

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag IAU58_RS19080 Protein ID WP_022649305.1
Coordinates 3961755..3962165 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag IAU58_RS19085 Protein ID WP_003863437.1
Coordinates 3962146..3962412 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAU58_RS19060 3957753..3959486 - 1734 WP_032610082.1 single-stranded-DNA-specific exonuclease RecJ -
IAU58_RS19065 3959492..3960205 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IAU58_RS19070 3960234..3961130 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
IAU58_RS19075 3961232..3961753 + 522 WP_003863440.1 flavodoxin FldB -
IAU58_RS19080 3961755..3962165 - 411 WP_022649305.1 protein YgfX Toxin
IAU58_RS19085 3962146..3962412 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
IAU58_RS19090 3962707..3963687 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
IAU58_RS19095 3963773..3964432 - 660 WP_003863433.1 hemolysin III family protein -
IAU58_RS19100 3964699..3965430 + 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
IAU58_RS19105 3965547..3966980 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T199251 WP_022649305.1 NZ_CP072945:c3962165-3961755 [Enterobacter sp. MGH 7]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T199251 NZ_CP097255:152436-152621 [Enterobacter bugandensis]
GTGAAAAGTGCGGATGTCATTACCGTTCTGATCGGCCACGGCTGGAAATGTGTCAGAACGAAAGGAAGCCATCATCAGTT
TCGCCATCCCGAACAGAAAGGGCTGGTTACTGTCCCACATCCTAAGAAGGATATTAAACCGGGCACGCTCGCGCAGATAT
GGCGGCAGGCGGGAATTAAACACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT199251 WP_003863437.1 NZ_CP072945:c3962412-3962146 [Enterobacter sp. MGH 7]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT199251 NZ_CP097255:152636-153043 [Enterobacter bugandensis]
ATGTTTTATCCGGCTTACATTCATTCTGACACCGACGGTAGCGCCAGCGGCTTTTTTCCTGACGTTCCAGGCTGTTTTTT
TGCAGGTGATTCCCTGGACGACGCTTTTCAGGATGCACGTGATGCGCTCACCGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTGCCTCTTCCGGGAAATGTCGAAGTGCACCTTGAAAATCACCCTGACGACTTCACGGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAAGCAGTTTGACGGCAGAGCCGAGCGTATCAACATCACGATGCCTCGACGTTTGCTGGTAAA
GATTGATTCCTTTGTTAGCGAGCATCCTCAGTTCGGTAATCGAAGCGCATTTCTGGCTGAGGCAGCACGTCGCGTGCTGC
CTGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References