Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2440439..2441178 Replicon chromosome
Accession NZ_CP072945
Organism Enterobacter sp. MGH 7

Toxin (Protein)


Gene name tacT Uniprot ID A0A837FFP9
Locus tag IAU58_RS11770 Protein ID WP_032609220.1
Coordinates 2440439..2440924 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag IAU58_RS11775 Protein ID WP_003857131.1
Coordinates 2440912..2441178 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAU58_RS11745 2435759..2436574 - 816 WP_012695470.1 aminoglycoside O-phosphotransferase APH(3')-Ia -
IAU58_RS11750 2436735..2437703 - 969 WP_013815099.1 IS5-like element IS903B family transposase -
IAU58_RS11755 2437735..2438106 - 372 Protein_2298 IS5/IS1182 family transposase -
IAU58_RS11760 2438181..2438813 + 633 WP_001567369.1 hypothetical protein -
IAU58_RS11765 2438842..2440245 - 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
IAU58_RS11770 2440439..2440924 - 486 WP_032609220.1 GNAT family N-acetyltransferase Toxin
IAU58_RS11775 2440912..2441178 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
IAU58_RS11780 2441242..2442171 - 930 WP_032609221.1 LysR family transcriptional regulator -
IAU58_RS11785 2442301..2443689 + 1389 WP_032609222.1 MFS transporter -
IAU58_RS11790 2443711..2444706 - 996 WP_023314163.1 DUF2891 domain-containing protein -
IAU58_RS11795 2444716..2445702 - 987 WP_003857123.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element aph(3')-Ia - 2349383..2471269 121886


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17554.26 Da        Isoelectric Point: 9.9658

>T199240 WP_032609220.1 NZ_CP072945:c2440924-2440439 [Enterobacter sp. MGH 7]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T199240 NZ_CP097252:c2584574-2584293 [Mesorhizobium opportunistum]
ATGATACGCTCGTTCAAGGACAAGACCAGCGAGGCCGTTTCGAACGGCAAGTCTCCAAAGGGCTTTCCATCGGACCTTGT
CCGATCAGCCCAACGGAAACTGTTCATGATCGACAACGCGACCGAGTTGTCGGACCTGAAGACGCCCCCAGGCAACAGGC
TTGAGTCCCTGAAAGGCAATCGGGCCGGCCAACACTCCATCCGCATCAACGATCAGTTTCGCATCTGCTTTCGCTGGGTG
AACGGACAAGCCGAGGGCGTCGAAATAACCGACTACCATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT199240 WP_003857131.1 NZ_CP072945:c2441178-2440912 [Enterobacter sp. MGH 7]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT199240 NZ_CP097252:c2584278-2583979 [Mesorhizobium opportunistum]
ATGCTGAACATCAACCCGCCTATCCATCCCGGAGAAATCCTTCGCGAGGAATACCTCGTCCCGCTTGGCCTGAAGCCGTA
TACGCTGGCCAAGAAGCTGCATGTGCCACGTACACGCATCGAGCGCCTGGCCGGAGAGACGACACCGGTAACGCCCGACA
CCGCCCTGCGCCTTGCGAAGTTTTTCGGAACCACGCCGCAGTTCTGGATGAACATGCAGGCGAGTTACGATCTTGCCGTG
GAGGGAGAGGCCAAGAAAGCCGATCTCGAAACGATCGAACGTTTGGAGACCGTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References