Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1264700..1265320 Replicon chromosome
Accession NZ_CP072945
Organism Enterobacter sp. MGH 7

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag IAU58_RS06065 Protein ID WP_015571250.1
Coordinates 1264700..1264918 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag IAU58_RS06070 Protein ID WP_006809850.1
Coordinates 1264946..1265320 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAU58_RS06035 1260712..1260972 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
IAU58_RS06040 1260975..1261115 + 141 WP_032608666.1 type B 50S ribosomal protein L36 -
IAU58_RS06045 1261112..1261822 - 711 WP_022650493.1 GNAT family protein -
IAU58_RS06050 1261924..1263384 + 1461 WP_032608667.1 PLP-dependent aminotransferase family protein -
IAU58_RS06055 1263356..1263823 - 468 WP_022650495.1 YlaC family protein -
IAU58_RS06060 1263940..1264491 - 552 WP_022650496.1 maltose O-acetyltransferase -
IAU58_RS06065 1264700..1264918 - 219 WP_015571250.1 HHA domain-containing protein Toxin
IAU58_RS06070 1264946..1265320 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
IAU58_RS06075 1265831..1268977 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
IAU58_RS06080 1269000..1270193 - 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-114)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T199239 WP_015571250.1 NZ_CP072945:c1264918-1264700 [Enterobacter sp. MGH 7]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T199239 NZ_CP097252:483030-483452 [Mesorhizobium opportunistum]
GTGAGAGTGCTGCTCGATACGAATGTCCTGTCCGAGGTGACAAGGCCGGAGCCGGACGCACGCGTTCTGGACTGGCTGGA
CGGGCTTGATGAGGACCGCTCATTCATCAGCGTCGTATCGATCGCCGAGATCCGGCGCGGCGTCGCCCTCATGGATGAGG
GCCGGAAACGCGAAGCCCTTGCCGAATGGCTCGCCCGGGACCTGCCGCAGCGCTTCGAGCAGAGGGTTTTGCCGGTGAAC
GAACCGGTTGCCTTGGCCTGGGGCGACCTGATGGGCCTTGCGAAGCGCCGCGGTCGCGGCCTCTCGTCGATGGACGGGCT
GATCGCAGCCACGGCGATCGCGCAGCAGCTCACCTTGGTAACGCGCAACACGAAGGATTTCGAAGGCTTTGGGATAGAAC
TCTTCGATCCCTGGACGGCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT199239 WP_006809850.1 NZ_CP072945:c1265320-1264946 [Enterobacter sp. MGH 7]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT199239 NZ_CP097252:482770-483033 [Mesorhizobium opportunistum]
ATGCTACCGTCGCCCAAAGACACCAATTGGACGGTCGCCGGGGCAAAAGCCCGGCTCTCGGAGGTTATCGAGCGCGCGCA
GTCATCGCCGCAGACGATCACCAGAAACGGCAAACCGAGCGTGGTTGTCGTCTCGGCCGAGGAATGGCAGCGCAAGACCG
TGCGCAAAGGTACGCTTGCGCAGTTCCTGCTGGAGTCACCACTGCGCGGCGCCGATCTCAACCTCGAGCGTCAGCGTGAC
GAGCCGCGTGACCTGCCGCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A837FFM2


Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References