Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1264700..1265320 | Replicon | chromosome |
Accession | NZ_CP072945 | ||
Organism | Enterobacter sp. MGH 7 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | A0A837FFM2 |
Locus tag | IAU58_RS06065 | Protein ID | WP_015571250.1 |
Coordinates | 1264700..1264918 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | F5RUW7 |
Locus tag | IAU58_RS06070 | Protein ID | WP_006809850.1 |
Coordinates | 1264946..1265320 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IAU58_RS06035 | 1260712..1260972 | + | 261 | WP_015571255.1 | type B 50S ribosomal protein L31 | - |
IAU58_RS06040 | 1260975..1261115 | + | 141 | WP_032608666.1 | type B 50S ribosomal protein L36 | - |
IAU58_RS06045 | 1261112..1261822 | - | 711 | WP_022650493.1 | GNAT family protein | - |
IAU58_RS06050 | 1261924..1263384 | + | 1461 | WP_032608667.1 | PLP-dependent aminotransferase family protein | - |
IAU58_RS06055 | 1263356..1263823 | - | 468 | WP_022650495.1 | YlaC family protein | - |
IAU58_RS06060 | 1263940..1264491 | - | 552 | WP_022650496.1 | maltose O-acetyltransferase | - |
IAU58_RS06065 | 1264700..1264918 | - | 219 | WP_015571250.1 | HHA domain-containing protein | Toxin |
IAU58_RS06070 | 1264946..1265320 | - | 375 | WP_006809850.1 | Hha toxicity modulator TomB | Antitoxin |
IAU58_RS06075 | 1265831..1268977 | - | 3147 | WP_022650497.1 | multidrug efflux RND transporter permease subunit AcrB | - |
IAU58_RS06080 | 1269000..1270193 | - | 1194 | WP_022650498.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8583.95 Da Isoelectric Point: 8.9008
>T199239 WP_015571250.1 NZ_CP072945:c1264918-1264700 [Enterobacter sp. MGH 7]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR
Download Length: 219 bp
>T199239 NZ_CP097252:483030-483452 [Mesorhizobium opportunistum]
GTGAGAGTGCTGCTCGATACGAATGTCCTGTCCGAGGTGACAAGGCCGGAGCCGGACGCACGCGTTCTGGACTGGCTGGA
CGGGCTTGATGAGGACCGCTCATTCATCAGCGTCGTATCGATCGCCGAGATCCGGCGCGGCGTCGCCCTCATGGATGAGG
GCCGGAAACGCGAAGCCCTTGCCGAATGGCTCGCCCGGGACCTGCCGCAGCGCTTCGAGCAGAGGGTTTTGCCGGTGAAC
GAACCGGTTGCCTTGGCCTGGGGCGACCTGATGGGCCTTGCGAAGCGCCGCGGTCGCGGCCTCTCGTCGATGGACGGGCT
GATCGCAGCCACGGCGATCGCGCAGCAGCTCACCTTGGTAACGCGCAACACGAAGGATTTCGAAGGCTTTGGGATAGAAC
TCTTCGATCCCTGGACGGCATGA
GTGAGAGTGCTGCTCGATACGAATGTCCTGTCCGAGGTGACAAGGCCGGAGCCGGACGCACGCGTTCTGGACTGGCTGGA
CGGGCTTGATGAGGACCGCTCATTCATCAGCGTCGTATCGATCGCCGAGATCCGGCGCGGCGTCGCCCTCATGGATGAGG
GCCGGAAACGCGAAGCCCTTGCCGAATGGCTCGCCCGGGACCTGCCGCAGCGCTTCGAGCAGAGGGTTTTGCCGGTGAAC
GAACCGGTTGCCTTGGCCTGGGGCGACCTGATGGGCCTTGCGAAGCGCCGCGGTCGCGGCCTCTCGTCGATGGACGGGCT
GATCGCAGCCACGGCGATCGCGCAGCAGCTCACCTTGGTAACGCGCAACACGAAGGATTTCGAAGGCTTTGGGATAGAAC
TCTTCGATCCCTGGACGGCATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14497.28 Da Isoelectric Point: 4.8989
>AT199239 WP_006809850.1 NZ_CP072945:c1265320-1264946 [Enterobacter sp. MGH 7]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC
Download Length: 375 bp
>AT199239 NZ_CP097252:482770-483033 [Mesorhizobium opportunistum]
ATGCTACCGTCGCCCAAAGACACCAATTGGACGGTCGCCGGGGCAAAAGCCCGGCTCTCGGAGGTTATCGAGCGCGCGCA
GTCATCGCCGCAGACGATCACCAGAAACGGCAAACCGAGCGTGGTTGTCGTCTCGGCCGAGGAATGGCAGCGCAAGACCG
TGCGCAAAGGTACGCTTGCGCAGTTCCTGCTGGAGTCACCACTGCGCGGCGCCGATCTCAACCTCGAGCGTCAGCGTGAC
GAGCCGCGTGACCTGCCGCTGTGA
ATGCTACCGTCGCCCAAAGACACCAATTGGACGGTCGCCGGGGCAAAAGCCCGGCTCTCGGAGGTTATCGAGCGCGCGCA
GTCATCGCCGCAGACGATCACCAGAAACGGCAAACCGAGCGTGGTTGTCGTCTCGGCCGAGGAATGGCAGCGCAAGACCG
TGCGCAAAGGTACGCTTGCGCAGTTCCTGCTGGAGTCACCACTGCGCGGCGCCGATCTCAACCTCGAGCGTCAGCGTGAC
GAGCCGCGTGACCTGCCGCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A837FFM2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A837FGN8 |