Detailed information of TA system TA199238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1041030..1041637
• Replicon: chromosome
• Accession: NZ_CP072945
• Organism: Enterobacter sp. MGH 7

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A4Q4AAS0
• Locus tag: IAU58_RS05030
• Protein ID: WP_057979982.1
• Coordinates: 1041030..1041215 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IAU58_RS05035
• Protein ID: WP_023315016.1
• Coordinates: 1041230..1041637 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAU58_RS05015	1036349..1038187	+	1839	WP_023323871.1	selenocysteine-specific translation elongation factor	-
IAU58_RS05020	1038191..1039075	-	885	WP_003860164.1	ROK family protein	-
IAU58_RS05025	1039242..1040780	+	1539	WP_006808612.1	aldehyde dehydrogenase AldB	-
IAU58_RS05030	1041030..1041215	+	186	WP_057979982.1	type II toxin-antitoxin system HicA family toxin	Toxin
IAU58_RS05035	1041230..1041637	+	408	WP_023315016.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IAU58_RS05040	1041641..1042717	-	1077	WP_023323870.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
IAU58_RS05045	1043178..1043633	+	456	WP_023323869.1	4Fe-4S dicluster domain-containing protein	-
IAU58_RS05050	1043641..1044894	-	1254	WP_015572749.1	valine--pyruvate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6852.08 Da
• Isoelectric Point: 11.5191

>T199238 WP_057979982.1 NZ_CP072945:1041030-1041215 [Enterobacter sp. MGH 7]
VKSADIITVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T199238 NZ_CP097252:c367819-367565 [Mesorhizobium opportunistum]
CTGAAAATCGTTTGGGATGAGCCGAAACGCGTAACGAACCTCAAAAACCGGGGTCTCGATTTTGCCGAACTCGATATCGA
GTTTTTTGCGACTTCAACCGTCCTCCCGGCCAAGGCCGGCCGGCTCAAGGCGATTGGCGAATTCGGAGAGATCATTCTCG
CCGTTATTTTTAAGCCGCTTGGTTTCGAAGCGATTTCGGTGATCTCGATGCGTCGTGCTAGCCGAAAGGAAAGGTCAGTA
TATGAACAAACCTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15205.20 Da
• Isoelectric Point: 4.5036

>AT199238 WP_023315016.1 NZ_CP072945:1041230-1041637 [Enterobacter sp. MGH 7]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEMLPLPGMVEAHLASHPEDFIGGQWL
LVDINMKQFEGRVERINITIPRRLLVKIDSFVSEHPQFTNRSAFLAEAARRVLPR

Nucleotide

• Length: 408 bp

>AT199238 NZ_CP097252:c367578-367267 [Mesorhizobium opportunistum]
ATGAACAAACCTAAGTCACGTATTCGGCCGCTTACCGATGAGGAGGAAGCGGAAATCCAAAGGCAAATCGCTGCTGATTC
CGACGACGCGGAGGCGACTGACGAGCAATTGGCGCGAGCCAAGCCTTTCGCGGAAGCGTTTCCGGAACTTTTCGAAAGCA
TAAGGCGCGCTCGTGGCCGGCCTCCTGTGGAAAAGCCCAAGCAAGTTGTGTCCATCCGTCTGGATCAGGACGTCGTCAGA
AAATTCAAGGCGACTGGCAAGGGCTGGCAGGCCAAGATAAATGAGGTATTGAAAAACGCGAAGGTAAGCTAG

Structures

Toxin

• AlphaFold DB: A0A4Q4AAS0