Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 675632..676311 Replicon chromosome
Accession NZ_CP072945
Organism Enterobacter sp. MGH 7

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag IAU58_RS03350 Protein ID WP_032608412.1
Coordinates 675970..676311 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag IAU58_RS03345 Protein ID WP_020456353.1
Coordinates 675632..675949 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAU58_RS03305 670921..671745 + 825 Protein_640 DUF945 domain-containing protein -
IAU58_RS03310 671954..672637 + 684 WP_020456346.1 DeoR family transcriptional regulator -
IAU58_RS26035 672690..672812 + 123 WP_020456347.1 hypothetical protein -
IAU58_RS03315 672876..673742 + 867 WP_032608409.1 hypothetical protein -
IAU58_RS03320 673870..674070 + 201 WP_050596949.1 DUF905 family protein -
IAU58_RS03325 674176..674634 + 459 WP_032608410.1 antirestriction protein -
IAU58_RS03330 674644..674862 + 219 WP_020456350.1 hypothetical protein -
IAU58_RS03335 674905..675384 + 480 WP_020456351.1 DNA repair protein RadC -
IAU58_RS03340 675393..675614 + 222 WP_032608411.1 DUF987 domain-containing protein -
IAU58_RS03345 675632..675949 + 318 WP_020456353.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IAU58_RS03350 675970..676311 + 342 WP_032608412.1 TA system toxin CbtA family protein Toxin
IAU58_RS03355 676566..677573 + 1008 WP_020456355.1 restriction endonuclease -
IAU58_RS03360 677754..678623 - 870 WP_032608413.1 HNH endonuclease -
IAU58_RS03365 678924..679397 + 474 WP_072163380.1 SymE family type I addiction module toxin -
IAU58_RS03370 679477..679848 - 372 WP_032608414.1 hypothetical protein -
IAU58_RS03375 679963..680211 - 249 WP_032608415.1 bacteriocin immunity protein -
IAU58_RS03380 680270..680494 - 225 WP_032608417.1 colicin E3-like toxin immunity protein -
IAU58_RS03385 680567..680818 - 252 WP_032608418.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA - 645252..696708 51456


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12747.73 Da        Isoelectric Point: 9.0060

>T199237 WP_032608412.1 NZ_CP072945:675970-676311 [Enterobacter sp. MGH 7]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T199237 NZ_CP097252:344657-345184 [Mesorhizobium opportunistum]
GTGACGCTTCCGTCCTGGCACGAAGAGGCGATTGCGAAACGGCACAATCGGAATTCCTTCGATTGCGGCGATACGCACAT
GAATGATTTTCTGCGGCGTTTCGCACGGCAAAGTCACGAGCAGAATGCCGCGAAGACCTTCTGTGCTGTTGATGACGCGG
CGCCAGAACGAATTCTAGGATTCTACACAATCGCACCCTCTGCCGTCGCTCACGAAAACGTGCCGGCAGCCATGACGAAG
GGCTTGGCGCGGCACGAGGTTTCCGGCTTCAAGCTCGCCCGCCTCGCAACCGACCTTACCGCCGCAGGGAATGGGCTCGG
AGGACAATTGCTTGCAGCCGCGGCGTTGCGTTGCCTGCGGCTTGCCGGCGAGGGCGGGGGCATCCTGCTCATTATCGATG
CCAAGAGTGAGCGCGCTGCGAAATGGTACGCCAGCTACGGTGTCGAGCGCCTTCAAGGATCGGATTTGACCCTGGCGATG
CCCCTGGCGACATTCGCAACCGATCTGCGCACCAAGGGACTGCTTTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11846.39 Da        Isoelectric Point: 5.5403

>AT199237 WP_020456353.1 NZ_CP072945:675632-675949 [Enterobacter sp. MGH 7]
MSNTTWGLQRDITPRLGARLVQEGNWLHYLADRASITGKFSEAECLKLDVVFPNFISQLESMLTTGEMNPSHAYCVTLYH
NGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 318 bp

>AT199237 NZ_CP097252:344382-344660 [Mesorhizobium opportunistum]
ATGCCGCGGCCCGCCGACAATAAGACCGAGCGTTATCAAATCCGCATTGCGCCGGCGCAAAAGGCGATGATTGCGCGGGC
GGCTGCCCTGTCGCATCAGGACGTGGCTGACTTCATCCTCAACAAGGTGGTGCCCGAAGCTCAGGCCGTGATCGAAGCGG
CCGAGGTCACGAAAGTATCAGACCGCGATTTCACACGCATACTCGACCTTTTGGAGCACCCGCCCAAACCCAACGCCAAG
TTGCGAGCAGCGATTGCAGCCTTGCCAGATACGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References