Detailed information of TA system TA199233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 671613..672132
• Replicon: chromosome
• Accession: NZ_CP072935
• Organism: Corynebacterium genitalium ATCC 33030 strain CCUG 38989

Toxin (Protein)

• Gene name: parE
• Uniprot ID: D7WF88
• Locus tag: KBP53_RS03275
• Protein ID: WP_005291483.1
• Coordinates: 671848..672132 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: D7WF89
• Locus tag: KBP53_RS03270
• Protein ID: WP_005291485.1
• Coordinates: 671613..671864 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KBP53_RS03255 (KBP53_03245)	667204..669036	-	1833	WP_005291491.1	metallophosphoesterase family protein	-
KBP53_RS03260 (KBP53_03250)	669191..669835	-	645	WP_005291489.1	DUF3239 domain-containing protein	-
KBP53_RS03265 (KBP53_03255)	669871..671511	-	1641	WP_005291487.1	DEAD/DEAH box helicase	-
KBP53_RS03270 (KBP53_03260)	671613..671864	+	252	WP_005291485.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
KBP53_RS03275 (KBP53_03265)	671848..672132	+	285	WP_005291483.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KBP53_RS03280 (KBP53_03270)	672161..673360	-	1200	WP_005291481.1	ABC transporter permease	-
KBP53_RS03285 (KBP53_03275)	673360..674238	-	879	WP_005291479.1	ATP-binding cassette domain-containing protein	-
KBP53_RS03290 (KBP53_03280)	674238..674756	-	519	WP_005291477.1	hypothetical protein	-
KBP53_RS03295 (KBP53_03285)	674753..675010	-	258	WP_040423815.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Antitoxin ParD (1-77)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10955.54 Da
• Isoelectric Point: 9.8132

>T199233 WP_005291483.1 NZ_CP072935:671848-672132 [Corynebacterium genitalium ATCC 33030]
MTYRLKEEAVEDLRGIWSYAETQWGPAQAERYLRTLERQFAWIADQPTSGKLVPGISGYRQRAAGSHMIIYRLDDRGVIV
IRVLHQKMDPSRHL

Nucleotide

• Length: 285 bp

>T199233 NZ_CP097248:2948076-2948486 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9513.76 Da
• Isoelectric Point: 4.8723

>AT199233 WP_005291485.1 NZ_CP072935:671613-671864 [Corynebacterium genitalium ATCC 33030]
MAKNTSVTLGPHYEEFIAQMVASGRYATSSEVIRAGLRMIEDYEQRLEVLRREIQKGEESGLAEDFDFNKFIEKMKRGND
IPA

Nucleotide

• Length: 252 bp

>AT199233 NZ_CP097248:2947829-2948095 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: D7WF88

Antitoxin

• AlphaFold DB: D7WF89