Detailed information of TA system TA199232

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 2067362..2067845
• Replicon: chromosome
• Accession: NZ_CP072934
• Organism: Corynebacterium pseudogenitalium strain CCUG 27540

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KBP54_RS09795
• Protein ID: WP_240492810.1
• Coordinates: 2067362..2067583 (-)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A1F1UQ19
• Locus tag: KBP54_RS09800
• Protein ID: WP_070361826.1
• Coordinates: 2067609..2067845 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KBP54_RS09780 (KBP54_09755)	2063779..2065068	-	1290	WP_070361829.1	adenylosuccinate synthase	-
KBP54_RS09785 (KBP54_09760)	2065119..2066003	+	885	WP_256005598.1	hypothetical protein	-
KBP54_RS09790 (KBP54_09765)	2066000..2067172	-	1173	WP_256000825.1	FUSC family protein	-
KBP54_RS09795 (KBP54_09770)	2067362..2067583	-	222	WP_240492810.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KBP54_RS09800 (KBP54_09775)	2067609..2067845	-	237	WP_070361826.1	ribbon-helix-helix protein, CopG family	Antitoxin
KBP54_RS09805 (KBP54_09780)	2068352..2069392	-	1041	WP_256006653.1	class II fructose-bisphosphate aldolase	-
KBP54_RS09810 (KBP54_09785)	2069438..2070649	-	1212	WP_256005600.1	glycoside hydrolase family 76 protein	-
KBP54_RS09815 (KBP54_09790)	2070662..2071327	-	666	WP_070361824.1	RNA methyltransferase	-
KBP54_RS09820 (KBP54_09795)	2071314..2071847	-	534	WP_256005602.1	orotate phosphoribosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-72)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-42)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8485.86 Da
• Isoelectric Point: 11.2567

>T199232 WP_240492810.1 NZ_CP072934:c2067583-2067362 [Corynebacterium pseudogenitalium]
VRRLDKQVQRRLFQVLGDLSRLNDPRVRGKALVGGMSGLWRWRIGDYRVIAEIQDDIVTVLVVDVGHRGEIYR

Nucleotide

• Length: 222 bp

>T199232 NZ_CP097248:2866611-2867096 [Klebsiella pneumoniae]
ATGATCTTGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8854.98 Da
• Isoelectric Point: 4.2508

>AT199232 WP_070361826.1 NZ_CP072934:c2067845-2067609 [Corynebacterium pseudogenitalium]
MSGSVISLRMDEVQKRRLDELATKTGRPKAFYIREAIEAYLDDAEYIYELQAEAEAVRRGELETVTLDELKAECGLAD

Nucleotide

• Length: 237 bp

>AT199232 NZ_CP097248:2866321-2866614 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1F1UQ19