Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PemK-MazE |
| Location | 638104..638645 | Replicon | chromosome |
| Accession | NZ_CP072933 | ||
| Organism | Xylella fastidiosa subsp. multiplex strain AlmaEM3 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | KBP49_RS02735 | Protein ID | WP_027700637.1 |
| Coordinates | 638322..638645 (+) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | KBP49_RS02730 | Protein ID | WP_027700636.1 |
| Coordinates | 638104..638325 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KBP49_RS02690 (KBP49_02690) | 634620..634844 | - | 225 | WP_247644824.1 | major capsid protein | - |
| KBP49_RS02695 (KBP49_02695) | 634853..635059 | - | 207 | WP_242412856.1 | hypothetical protein | - |
| KBP49_RS02700 (KBP49_02700) | 635062..635409 | - | 348 | WP_242412857.1 | hypothetical protein | - |
| KBP49_RS02705 (KBP49_02705) | 635628..636215 | - | 588 | WP_071869977.1 | hypothetical protein | - |
| KBP49_RS02710 (KBP49_02710) | 636475..636675 | + | 201 | WP_161594848.1 | hypothetical protein | - |
| KBP49_RS02715 (KBP49_02715) | 636800..636982 | - | 183 | WP_058564706.1 | hypothetical protein | - |
| KBP49_RS02720 (KBP49_02720) | 637030..637341 | - | 312 | WP_071869979.1 | hypothetical protein | - |
| KBP49_RS02725 (KBP49_02725) | 637481..637861 | + | 381 | WP_140161065.1 | DUF3693 domain-containing protein | - |
| KBP49_RS02730 (KBP49_02730) | 638104..638325 | + | 222 | WP_027700636.1 | antitoxin MazE family protein | Antitoxin |
| KBP49_RS02735 (KBP49_02735) | 638322..638645 | + | 324 | WP_027700637.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| KBP49_RS02740 (KBP49_02740) | 638679..639509 | - | 831 | WP_027700638.1 | site-specific integrase | - |
| KBP49_RS02745 (KBP49_02745) | 639771..640019 | + | 249 | WP_140162070.1 | hypothetical protein | - |
| KBP49_RS02750 (KBP49_02750) | 640034..641167 | - | 1134 | WP_071869985.1 | zonular occludens toxin domain-containing protein | - |
| KBP49_RS02755 (KBP49_02755) | 641167..641508 | - | 342 | WP_027700640.1 | DUF2523 family protein | - |
| KBP49_RS02760 (KBP49_02760) | 641512..642960 | - | 1449 | WP_210967976.1 | virulence factor TspB C-terminal domain-related protein | - |
| KBP49_RS02765 (KBP49_02765) | 643039..643263 | - | 225 | WP_242412860.1 | major capsid protein | - |
| KBP49_RS02770 (KBP49_02770) | 643272..643478 | - | 207 | WP_242412856.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 630237..648898 | 18661 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 11799.86 Da Isoelectric Point: 7.9848
>T199224 WP_027700637.1 NZ_CP072933:638322-638645 [Xylella fastidiosa subsp. multiplex]
MIQRGDLVTVSLQGDYGKPRPALIVQSDLLTELDSVVLCPVTSDLRNAIFRVTVEPTAANGLRTLSQVMVDKISTLPRNK
ISEPFGRLNDERMKAIERALLLIIGII
MIQRGDLVTVSLQGDYGKPRPALIVQSDLLTELDSVVLCPVTSDLRNAIFRVTVEPTAANGLRTLSQVMVDKISTLPRNK
ISEPFGRLNDERMKAIERALLLIIGII
Download Length: 324 bp
>T199224 NZ_CP097245:3545269-3545670 [Leptospira santarosai]
ATGACCCACTATTTGTTGGATACGAATATTTGTATTTATATAATAAATCAAAAACCAGAATCTGTTTATAAGAAATTTAA
GAAGATTAAATTAGAGAACATTTTTATTTCATCAATTACAGAATTTGAGCTAAAGTATGACGTTCAAAAAAGTCTTCATT
TTGAGAGGAATTTAAAAGTCTTAGAAGAGTTTCTGGGTTACTTGAATATTCTTCAATTCGTTAGCAAAGACGCTAGTAAA
GCCGCAAAAATTCGAGTAGAGTTAGAAAGAGTAGGTAAACCAATAGGTCCATTTGATCTTTTAATAGCGTCTCAAGCATT
GGCAAATAAGCTTACTCTTGTGACAAACAACGAAAAAGAATTCGCTAGAATTAAAGAGATAAAAATGGAAAGCTGGCTTT
AA
ATGACCCACTATTTGTTGGATACGAATATTTGTATTTATATAATAAATCAAAAACCAGAATCTGTTTATAAGAAATTTAA
GAAGATTAAATTAGAGAACATTTTTATTTCATCAATTACAGAATTTGAGCTAAAGTATGACGTTCAAAAAAGTCTTCATT
TTGAGAGGAATTTAAAAGTCTTAGAAGAGTTTCTGGGTTACTTGAATATTCTTCAATTCGTTAGCAAAGACGCTAGTAAA
GCCGCAAAAATTCGAGTAGAGTTAGAAAGAGTAGGTAAACCAATAGGTCCATTTGATCTTTTAATAGCGTCTCAAGCATT
GGCAAATAAGCTTACTCTTGTGACAAACAACGAAAAAGAATTCGCTAGAATTAAAGAGATAAAAATGGAAAGCTGGCTTT
AA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8458.64 Da Isoelectric Point: 9.3510
>AT199224 WP_027700636.1 NZ_CP072933:638104-638325 [Xylella fastidiosa subsp. multiplex]
MTSTHRPDSKIVHHREQMRAAGLRPMQLWVPDTRTPEFAAEIRSQCRALKGDQAEADALRFTEKTMTHIEGWK
MTSTHRPDSKIVHHREQMRAAGLRPMQLWVPDTRTPEFAAEIRSQCRALKGDQAEADALRFTEKTMTHIEGWK
Download Length: 222 bp
>AT199224 NZ_CP097245:3545039-3545272 [Leptospira santarosai]
ATTCCTCATTATTCTAAAGAGCGCCTACAAGGCGATAGCCAGGCAATTCGCCTGCCAAAAAACTATCGTTTTAAAGGTAG
AGAAGTCTATATACGAAAAGACGGGGACAATGTTATTTTAACTCCAATAGATGATATCGTGGATCGATTTTGGAATACGC
TTCATAATTTTTCTGACGATCTCATAATAGATCGAAACCAACCAAATGAGTATGACAAAAGAAATGGAATATGA
ATTCCTCATTATTCTAAAGAGCGCCTACAAGGCGATAGCCAGGCAATTCGCCTGCCAAAAAACTATCGTTTTAAAGGTAG
AGAAGTCTATATACGAAAAGACGGGGACAATGTTATTTTAACTCCAATAGATGATATCGTGGATCGATTTTGGAATACGC
TTCATAATTTTTCTGACGATCTCATAATAGATCGAAACCAACCAAATGAGTATGACAAAAGAAATGGAATATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|