Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
| Location | 732092..732614 | Replicon | chromosome |
| Accession | NZ_CP072932 | ||
| Organism | Xylella fastidiosa subsp. multiplex strain BB08-1 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A060HA53 |
| Locus tag | KBP48_RS03235 | Protein ID | WP_038229230.1 |
| Coordinates | 732092..732379 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A060HDF9 |
| Locus tag | KBP48_RS03240 | Protein ID | WP_004085758.1 |
| Coordinates | 732372..732614 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KBP48_RS03200 (KBP48_03200) | 727839..728165 | - | 327 | WP_140189688.1 | hypothetical protein | - |
| KBP48_RS03205 (KBP48_03205) | 728165..728422 | - | 258 | WP_171946801.1 | hypothetical protein | - |
| KBP48_RS03210 (KBP48_03210) | 728901..729254 | - | 354 | WP_071870005.1 | hypothetical protein | - |
| KBP48_RS03215 (KBP48_03215) | 729256..729483 | - | 228 | WP_247644621.1 | phage holin family protein | - |
| KBP48_RS03220 (KBP48_03220) | 729569..730195 | + | 627 | WP_140189401.1 | IS607 family transposase | - |
| KBP48_RS03225 (KBP48_03225) | 730189..731421 | + | 1233 | WP_140160997.1 | RNA-guided endonuclease TnpB family protein | - |
| KBP48_RS03230 (KBP48_03230) | 731438..732004 | - | 567 | WP_004085755.1 | recombinase family protein | - |
| KBP48_RS03235 (KBP48_03235) | 732092..732379 | - | 288 | WP_038229230.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KBP48_RS03240 (KBP48_03240) | 732372..732614 | - | 243 | WP_004085758.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| KBP48_RS03245 (KBP48_03245) | 732865..733011 | + | 147 | WP_230577682.1 | transposase | - |
| KBP48_RS03250 (KBP48_03250) | 733210..734109 | + | 900 | WP_140189706.1 | TauD/TfdA family dioxygenase | - |
| KBP48_RS03255 (KBP48_03255) | 734120..735025 | + | 906 | WP_040123139.1 | AEC family transporter | - |
| KBP48_RS11395 | 735400..735627 | + | 228 | WP_233341840.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| KBP48_RS03265 (KBP48_03265) | 735580..735831 | - | 252 | Protein_629 | conjugal transfer protein TrbJ | - |
| KBP48_RS03270 (KBP48_03270) | 735960..736994 | - | 1035 | WP_071869505.1 | hypothetical protein | - |
| KBP48_RS03275 (KBP48_03275) | 737370..737609 | + | 240 | WP_004085761.1 | ribbon-helix-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 731438..732004 | 566 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11163.63 Da Isoelectric Point: 5.9570
>T199217 WP_038229230.1 NZ_CP072932:c732379-732092 [Xylella fastidiosa subsp. multiplex]
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLTDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLTDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL
Download Length: 288 bp
>T199217 NZ_CP097238:281389-281673 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACCATTTAACCAAACACAGAAATTAA
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACCATTTAACCAAACACAGAAATTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8774.77 Da Isoelectric Point: 6.9881
>AT199217 WP_004085758.1 NZ_CP072932:c732614-732372 [Xylella fastidiosa subsp. multiplex]
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG
Download Length: 243 bp
>AT199217 NZ_CP097238:281151-281399 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGTTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGTTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HA53 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HDF9 |