Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 475472..476058 Replicon chromosome
Accession NZ_CP072932
Organism Xylella fastidiosa subsp. multiplex strain BB08-1

Toxin (Protein)


Gene name hicA Uniprot ID Q87BV5
Locus tag KBP48_RS01990 Protein ID WP_004089517.1
Coordinates 475804..476058 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B2I6C9
Locus tag KBP48_RS01985 Protein ID WP_004085025.1
Coordinates 475472..475807 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBP48_RS01955 (KBP48_01955) 472246..472779 - 534 WP_128283774.1 terminase small subunit -
KBP48_RS01960 (KBP48_01960) 472952..473176 - 225 WP_140189726.1 hypothetical protein -
KBP48_RS01965 (KBP48_01965) 473178..473639 - 462 WP_140189727.1 hypothetical protein -
KBP48_RS01970 (KBP48_01970) 473629..473958 - 330 WP_173391721.1 phage holin family protein -
KBP48_RS01975 (KBP48_01975) 473951..474451 - 501 WP_140189728.1 lysozyme -
KBP48_RS01980 (KBP48_01980) 474551..475282 - 732 WP_140189729.1 site-specific DNA-methyltransferase -
KBP48_RS01985 (KBP48_01985) 475472..475807 - 336 WP_004085025.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KBP48_RS01990 (KBP48_01990) 475804..476058 - 255 WP_004089517.1 type II toxin-antitoxin system HicA family toxin Toxin
KBP48_RS01995 (KBP48_01995) 476138..476833 - 696 Protein_378 hypothetical protein -
KBP48_RS02000 (KBP48_02000) 477309..478577 + 1269 WP_247644610.1 DNA polymerase -
KBP48_RS02005 (KBP48_02005) 478574..478852 + 279 WP_004086077.1 VRR-NUC domain-containing protein -
KBP48_RS02010 (KBP48_02010) 478854..479270 - 417 WP_140189730.1 DUF1640 domain-containing protein -
KBP48_RS02015 (KBP48_02015) 479355..480773 + 1419 WP_140189733.1 DEAD/DEAH box helicase -
KBP48_RS02020 (KBP48_02020) 480770..480934 + 165 WP_200873170.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 445698..484693 38995


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9639.14 Da        Isoelectric Point: 11.2766

>T199216 WP_004089517.1 NZ_CP072932:c476058-475804 [Xylella fastidiosa subsp. multiplex]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Download         Length: 255 bp

>T199216 NZ_CP097238:163321-163803 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12324.07 Da        Isoelectric Point: 5.6556

>AT199216 WP_004085025.1 NZ_CP072932:c475807-475472 [Xylella fastidiosa subsp. multiplex]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Download         Length: 336 bp

>AT199216 NZ_CP097238:163052-163330 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87BV5

Antitoxin

Source ID Structure
AlphaFold DB A0A060HAK5

References