Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1736839..1737470 Replicon chromosome
Accession NZ_CP072916
Organism Comamonas aquatica strain NEB418

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KAQ61_RS08190 Protein ID WP_210931300.1
Coordinates 1737069..1737470 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KAQ61_RS08185 Protein ID WP_042419946.1
Coordinates 1736839..1737072 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAQ61_RS08170 (KAQ61_08170) 1732053..1732562 + 510 WP_244983023.1 hypothetical protein -
KAQ61_RS08175 (KAQ61_08175) 1732991..1736065 + 3075 WP_210931298.1 DUF499 domain-containing protein -
KAQ61_RS08180 (KAQ61_08180) 1736068..1736694 + 627 WP_052369990.1 DUF3780 domain-containing protein -
KAQ61_RS08185 (KAQ61_08185) 1736839..1737072 + 234 WP_042419946.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KAQ61_RS08190 (KAQ61_08190) 1737069..1737470 + 402 WP_210931300.1 type II toxin-antitoxin system VapC family toxin Toxin
KAQ61_RS08195 (KAQ61_08195) 1737540..1740569 + 3030 WP_210931302.1 DUF1156 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14390.69 Da        Isoelectric Point: 5.7923

>T199214 WP_210931300.1 NZ_CP072916:1737069-1737470 [Comamonas aquatica]
MILLDTNICIYIINAKPPTVLARFQQYRMGDVGLCSVVAAELAFGVAKSGSARNRQALEMFLAPLTILPFDDAAVWAYGD
LRADLERRGTPIGALDTMIAAHALSQQALLVTNNTREFAKVPGLQLDNWAAAT

Download         Length: 402 bp

>T199214 NZ_CP097237:c4633833-4632511 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCACCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8655.75 Da        Isoelectric Point: 5.7551

>AT199214 WP_042419946.1 NZ_CP072916:1736839-1737072 [Comamonas aquatica]
MDTARLFQSGRSQAVRLPKEYRFTGTEVVVKHFGNGVLLLPADNPWQTLQAGLAAFEPGFVLTREQPDTQQRDEINP

Download         Length: 234 bp

>AT199214 NZ_CP097237:c4634099-4633833 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References