Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5126982..5127727 Replicon chromosome
Accession NZ_CP072914
Organism Klebsiella oxytoca isolate KoPF10

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KAT64_RS24090 Protein ID WP_210669460.1
Coordinates 5126982..5127344 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KAT64_RS24095 Protein ID WP_210669811.1
Coordinates 5127401..5127727 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAT64_RS24060 (KAT64_24060) 5122388..5122711 + 324 WP_210669456.1 endoribonuclease SymE -
KAT64_RS24065 (KAT64_24065) 5122870..5123304 + 435 WP_032728836.1 VOC family protein -
KAT64_RS24070 (KAT64_24070) 5123470..5124213 + 744 WP_070556690.1 hypothetical protein -
KAT64_RS24075 (KAT64_24075) 5124382..5125185 - 804 WP_210669457.1 helix-turn-helix transcriptional regulator -
KAT64_RS24080 (KAT64_24080) 5125563..5125961 - 399 WP_210669458.1 hypothetical protein -
KAT64_RS24085 (KAT64_24085) 5126029..5126871 - 843 WP_210669459.1 DUF4942 domain-containing protein -
KAT64_RS24090 (KAT64_24090) 5126982..5127344 - 363 WP_210669460.1 TA system toxin CbtA family protein Toxin
KAT64_RS24095 (KAT64_24095) 5127401..5127727 - 327 WP_210669811.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KAT64_RS24100 (KAT64_24100) 5127785..5128006 - 222 WP_210669461.1 DUF987 domain-containing protein -
KAT64_RS24105 (KAT64_24105) 5128020..5128499 - 480 WP_210669462.1 DNA repair protein RadC -
KAT64_RS24110 (KAT64_24110) 5128511..5128960 - 450 WP_210669463.1 antirestriction protein -
KAT64_RS24115 (KAT64_24115) 5128993..5129814 - 822 WP_150872347.1 DUF932 domain-containing protein -
KAT64_RS27530 5130491..5130649 + 159 Protein_4753 transposase -
KAT64_RS24125 (KAT64_24125) 5130785..5131873 - 1089 WP_210669464.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5122388..5164511 42123


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(7-110)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13580.52 Da        Isoelectric Point: 6.8697

>T199213 WP_210669460.1 NZ_CP072914:c5127344-5126982 [Klebsiella oxytoca]
MQTTLPFMRAVSSRPSPVDVWQTLLTCLLEHHYGLTLNDTPFSDEQVIQQHIDAGISLSDALNFIVEKYELVRTDRPGFS
IREQSPFITPIDILRARKAAGLMNRGTYKEVTAITRGQHP

Download         Length: 363 bp

>T199213 NZ_CP097237:3884160-3884262 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12071.66 Da        Isoelectric Point: 6.4749

>AT199213 WP_210669811.1 NZ_CP072914:c5127727-5127401 [Klebsiella oxytoca]
ISEPWWGLRHSASPCFGARLVQEGNRLHYLADRANFDGQFCDADLRHLDQSFPVLIKQLELLLTSGELNPRHQHCVTLYA
KGLTCEADTLGSHGYVYIAIYSTPIATA

Download         Length: 327 bp

>AT199213 NZ_CP097237:c3884269-3884124 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References