Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 918468..919239 Replicon chromosome
Accession NZ_CP072914
Organism Klebsiella oxytoca isolate KoPF10

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KAT64_RS04435 Protein ID WP_210669602.1
Coordinates 918850..919239 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KAT64_RS04430 Protein ID WP_210669790.1
Coordinates 918468..918794 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAT64_RS04390 (KAT64_04390) 913648..913983 + 336 WP_210669597.1 hypothetical protein -
KAT64_RS27335 914455..914670 - 216 WP_224257940.1 hypothetical protein -
KAT64_RS27340 914667..914945 - 279 WP_224257941.1 transposase -
KAT64_RS27550 915025..915153 - 129 WP_266097632.1 transposase domain-containing protein -
KAT64_RS27555 915184..915522 - 339 Protein_868 transposase -
KAT64_RS04405 (KAT64_04405) 915561..915710 - 150 WP_224257942.1 transposase -
KAT64_RS04410 (KAT64_04410) 916381..917202 + 822 WP_210669598.1 DUF932 domain-containing protein -
KAT64_RS04415 (KAT64_04415) 917235..917684 + 450 WP_210669599.1 antirestriction protein -
KAT64_RS04420 (KAT64_04420) 917696..918175 + 480 WP_210669600.1 DNA repair protein RadC -
KAT64_RS04425 (KAT64_04425) 918189..918410 + 222 WP_210669601.1 DUF987 family protein -
KAT64_RS04430 (KAT64_04430) 918468..918794 + 327 WP_210669790.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KAT64_RS04435 (KAT64_04435) 918850..919239 + 390 WP_210669602.1 TA system toxin CbtA family protein Toxin
KAT64_RS04440 (KAT64_04440) 919326..920165 + 840 WP_210669603.1 DUF4942 domain-containing protein -
KAT64_RS04445 (KAT64_04445) 920598..921491 + 894 WP_064356296.1 LysR family transcriptional regulator -
KAT64_RS04450 (KAT64_04450) 921516..922505 - 990 WP_135800556.1 aldo/keto reductase -
KAT64_RS04455 (KAT64_04455) 922532..923383 - 852 WP_210669604.1 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(8-111)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14509.65 Da        Isoelectric Point: 8.5448

>T199201 WP_210669602.1 NZ_CP072914:918850-919239 [Klebsiella oxytoca]
MQTKSFPLMRAALSRPSPVDVWQALLTSLLEHHYGLTLNDTPFSDEQVIQQHIDAGISLVDALNFIVEKYELVRIDRPGF
SIMEQSPFITPIDILRARKATGLMNRGTYKEVTAITRGQQPQANTSGKR

Download         Length: 390 bp

>T199201 NZ_CP097233:130161-130631 [Klebsiella pneumoniae]
GTGATCTTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12132.76 Da        Isoelectric Point: 6.3163

>AT199201 WP_210669790.1 NZ_CP072914:918468-918794 [Klebsiella oxytoca]
ISEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANFDGQFCDADLRHLDQSFPVLMKQLELMLTSGELNPRHQHGVTLYA
KGLACEADTLGSHGYVYIAIYPAPVTTE

Download         Length: 327 bp

>AT199201 NZ_CP097233:129721-130164 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References