Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 861463..862120 Replicon chromosome
Accession NZ_CP072914
Organism Klebsiella oxytoca isolate KoPF10

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag KAT64_RS04150 Protein ID WP_004105559.1
Coordinates 861710..862120 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag KAT64_RS04145 Protein ID WP_004105561.1
Coordinates 861463..861729 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAT64_RS04120 (KAT64_04120) 856642..858075 - 1434 WP_004105576.1 6-phospho-beta-glucosidase -
KAT64_RS04125 (KAT64_04125) 858196..858924 - 729 WP_064352017.1 MurR/RpiR family transcriptional regulator -
KAT64_RS04130 (KAT64_04130) 858975..859286 + 312 WP_004105571.1 N(4)-acetylcytidine aminohydrolase -
KAT64_RS04135 (KAT64_04135) 859448..860107 + 660 WP_064344096.1 hemolysin III family protein -
KAT64_RS04140 (KAT64_04140) 860236..861219 - 984 WP_064397252.1 tRNA-modifying protein YgfZ -
KAT64_RS04145 (KAT64_04145) 861463..861729 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
KAT64_RS04150 (KAT64_04150) 861710..862120 + 411 WP_004105559.1 protein YgfX Toxin
KAT64_RS04155 (KAT64_04155) 862129..862650 - 522 WP_004105557.1 flavodoxin FldB -
KAT64_RS04160 (KAT64_04160) 862772..863668 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
KAT64_RS04165 (KAT64_04165) 863691..864404 + 714 WP_004105554.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KAT64_RS04170 (KAT64_04170) 864410..866143 + 1734 WP_024274698.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T199200 WP_004105559.1 NZ_CP072914:861710-862120 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

>T199200 NZ_CP097232:4192011-4192421 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGAAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT199200 WP_004105561.1 NZ_CP072914:861463-861729 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT199200 NZ_CP097232:4191764-4192030 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References