Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 641675..642267 Replicon chromosome
Accession NZ_CP072914
Organism Klebsiella oxytoca isolate KoPF10

Toxin (Protein)


Gene name doc Uniprot ID A0A7H4PHG5
Locus tag KAT64_RS03105 Protein ID WP_004105955.1
Coordinates 641893..642267 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2J4YM08
Locus tag KAT64_RS03100 Protein ID WP_004105957.1
Coordinates 641675..641896 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAT64_RS03080 (KAT64_03080) 637236..637790 + 555 Protein_606 YgjV family protein -
KAT64_RS03085 (KAT64_03085) 637805..639052 - 1248 WP_004105963.1 serine/threonine transporter SstT -
KAT64_RS03090 (KAT64_03090) 639307..640275 - 969 WP_210669564.1 TerC family protein -
KAT64_RS03095 (KAT64_03095) 640526..641515 - 990 WP_064351610.1 Gfo/Idh/MocA family oxidoreductase -
KAT64_RS03100 (KAT64_03100) 641675..641896 + 222 WP_004105957.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KAT64_RS03105 (KAT64_03105) 641893..642267 + 375 WP_004105955.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KAT64_RS03110 (KAT64_03110) 642247..642750 - 504 WP_070556312.1 M48 family metallopeptidase -
KAT64_RS03115 (KAT64_03115) 642829..644472 - 1644 WP_004115710.1 glycoside hydrolase family 43 protein -
KAT64_RS03120 (KAT64_03120) 644601..645467 - 867 WP_004105950.1 AraC family transcriptional regulator -
KAT64_RS03125 (KAT64_03125) 645575..646918 + 1344 WP_004105949.1 glycoside-pentoside-hexuronide (GPH):cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13895.93 Da        Isoelectric Point: 6.0769

>T199199 WP_004105955.1 NZ_CP072914:641893-642267 [Klebsiella oxytoca]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHYEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

>T199199 NZ_CP097232:3723013-3723381 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8185.19 Da        Isoelectric Point: 5.7996

>AT199199 WP_004105957.1 NZ_CP072914:641675-641896 [Klebsiella oxytoca]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp

>AT199199 NZ_CP097232:3722795-3723016 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4PHG5

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4YM08

References