199198

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 84074..85104 Replicon chromosome
Accession NZ_CP072914
Organism Klebsiella oxytoca isolate KoPF10

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag KAT64_RS00420 Protein ID WP_017145221.1
Coordinates 84529..85104 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag KAT64_RS00415 Protein ID WP_004106993.1
Coordinates 84074..84529 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAT64_RS00390 (KAT64_00390) 79824..80777 + 954 WP_135800215.1 helix-turn-helix domain-containing protein -
KAT64_RS00395 (KAT64_00395) 80774..81823 - 1050 WP_004107002.1 NAD(P)-dependent alcohol dehydrogenase -
KAT64_RS00400 (KAT64_00400) 81982..82284 - 303 WP_049127699.1 putative quinol monooxygenase -
KAT64_RS00405 (KAT64_00405) 82286..83293 - 1008 WP_017145218.1 zinc-binding alcohol dehydrogenase family protein -
KAT64_RS00410 (KAT64_00410) 83406..83873 - 468 WP_064344103.1 DUF3237 domain-containing protein -
KAT64_RS00415 (KAT64_00415) 84074..84529 + 456 WP_004106993.1 helix-turn-helix domain-containing protein Antitoxin
KAT64_RS00420 (KAT64_00420) 84529..85104 + 576 WP_017145221.1 PIN domain-containing protein Toxin
KAT64_RS27545 85383..85505 + 123 WP_094298907.1 hypothetical protein -
KAT64_RS00430 (KAT64_00430) 85929..87323 + 1395 WP_070556449.1 glycoside-pentoside-hexuronide family transporter -
KAT64_RS00435 (KAT64_00435) 87337..89655 + 2319 WP_016809955.1 alpha-xylosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

Helix-turn-helix domain, group 17

(82-130)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21806.46 Da        Isoelectric Point: 6.9659

>T199198 WP_017145221.1 NZ_CP072914:84529-85104 [Klebsiella oxytoca]
MRHSPYPVILDACVLYPARLRDLLMHLGIAGLYQPKWSRCIQDEWCRNLIANRPDILPETLQRTVKMMNSALPDANVTGY
KGLISNLHLPDPNDRHVLAAAIRAKAEIIVTLNHKDFPPELLGPYEIETLHPDAFISDLFDLNHALTLEAVRRQRLSLKH
PSMAVDEFLEMLLKQGLPMTVKELAHYQYAI

Download         Length: 576 bp

>T199198 NZ_CP097232:c3285982-3285599 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 17068.56 Da        Isoelectric Point: 6.4953

>AT199198 WP_004106993.1 NZ_CP072914:84074-84529 [Klebsiella oxytoca]
MTTLTHLNLPDRQESELAQRGQRELAAYLSTRLETQRIAIVGEDDKAHTIELPTSALTLLMEILGELASGNAVQIVPVHA
ELTTQEAANILNVSRPHMVKLLEARKLPFHKTGRHRRVLFADLMEYKKRREQESLDAMQSLADQAQDLGMY

Download         Length: 456 bp

>AT199198 NZ_CP097232:c3286224-3285982 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References