Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1566692..1567319 Replicon chromosome
Accession NZ_CP072913
Organism Pseudomonas sp. Tri1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag J9870_RS06980 Protein ID WP_210643264.1
Coordinates 1567104..1567319 (-) Length 72 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J9870_RS06975 Protein ID WP_210643263.1
Coordinates 1566692..1567102 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9870_RS06945 1562095..1562511 + 417 WP_210643257.1 VOC family protein -
J9870_RS06950 1562682..1564031 + 1350 WP_210643258.1 diguanylate cyclase -
J9870_RS06955 1564309..1564812 + 504 WP_210643259.1 DUF4142 domain-containing protein -
J9870_RS06960 1564889..1565797 + 909 WP_210643260.1 SDR family oxidoreductase -
J9870_RS06965 1565846..1566250 - 405 WP_210643261.1 low affinity iron permease family protein -
J9870_RS06970 1566425..1566571 + 147 WP_210643262.1 hypothetical protein -
J9870_RS06975 1566692..1567102 - 411 WP_210643263.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J9870_RS06980 1567104..1567319 - 216 WP_210643264.1 type II toxin-antitoxin system HicA family toxin Toxin
J9870_RS06985 1567602..1568231 - 630 WP_210643265.1 LysE family translocator -
J9870_RS06990 1568375..1568857 + 483 WP_134923166.1 Lrp/AsnC family transcriptional regulator -
J9870_RS06995 1568974..1569273 - 300 WP_210643266.1 DUF3077 domain-containing protein -
J9870_RS07000 1570506..1571363 + 858 WP_210643267.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1562095..1581282 19187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 7885.13 Da        Isoelectric Point: 10.2823

>T199196 WP_210643264.1 NZ_CP072913:c1567319-1567104 [Pseudomonas sp. Tri1]
VNSRFLISQIIADGWYLVRVRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALLQTASCATSAEDD

Download         Length: 216 bp

>T199196 NZ_CP097232:c2817429-2817145 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14762.85 Da        Isoelectric Point: 4.7368

>AT199196 WP_210643263.1 NZ_CP072913:c1567102-1566692 [Pseudomonas sp. Tri1]
MLYPIAISMGDEKHAWGVEVPDIPGCFSAGDDLDEAMAMAREAIEGHFEILAEDGSAIPPANTVTLHAANPKYAGCTWAL
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQGR

Download         Length: 411 bp

>AT199196 NZ_CP097232:c2817661-2817419 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References