Detailed information of TA system TA199195

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 285247..285923
• Replicon: chromosome
• Accession: NZ_CP072913
• Organism: Pseudomonas sp. Tri1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: J9870_RS01225
• Protein ID: WP_134922407.1
• Coordinates: 285247..285429 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: J9870_RS01230
• Protein ID: WP_210645067.1
• Coordinates: 285522..285923 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9870_RS01210	281267..283228	+	1962	WP_210645065.1	choline transporter BetT	-
J9870_RS01215	283377..284117	-	741	WP_210642345.1	SDR family oxidoreductase	-
J9870_RS01220	284234..285124	+	891	WP_210642346.1	LysR family transcriptional regulator	-
J9870_RS01225	285247..285429	+	183	WP_134922407.1	type II toxin-antitoxin system HicA family toxin	Toxin
J9870_RS01230	285522..285923	+	402	WP_210645067.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J9870_RS01235	285982..287019	+	1038	WP_210642347.1	L-glyceraldehyde 3-phosphate reductase	-
J9870_RS01240	287076..287918	-	843	WP_210642348.1	taurine dioxygenase	-
J9870_RS01245	287969..288808	-	840	WP_210642349.1	taurine ABC transporter permease TauC	-
J9870_RS01250	288805..289599	-	795	WP_210642350.1	taurine ABC transporter ATP-binding subunit	-
J9870_RS01255	289625..290602	-	978	WP_210642351.1	taurine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6867.02 Da
• Isoelectric Point: 10.7459

>T199195 WP_134922407.1 NZ_CP072913:285247-285429 [Pseudomonas sp. Tri1]
MRSREMIRKIEEDGWYLVAVKGSHHQYKHPFKAGRVTIKHPDADLPRGTIASILKQAGLK

Nucleotide

• Length: 183 bp

>T199195 NZ_CP097232:c2707110-2706577 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14737.47 Da
• Isoelectric Point: 4.4915

>AT199195 WP_210645067.1 NZ_CP072913:285522-285923 [Pseudomonas sp. Tri1]
MKFPVVLHKDADSEYGVTVPDVPGCFSAGSTVNQAFENVKEALSLHYEGLIADGEPLPQIHEIDDHLDNPQYVGGIWGVV
EFDVTPYFGKSVRFNATLPEQLLERIDQTVRRDQRYSSRSGFLAAAALRELSA

Nucleotide

• Length: 402 bp

>AT199195 NZ_CP097232:c2707387-2707121 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA