199192

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 283523..284045 Replicon plasmid pKpCol17ndm
Accession NZ_CP072906
Organism Klebsiella pneumoniae strain COL17

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag GQ627_RS27685 Protein ID WP_004181778.1
Coordinates 283761..284045 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag GQ627_RS27680 Protein ID WP_025368601.1
Coordinates 283523..283771 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ627_RS27660 (GQ627_0ndm00332) 278723..279559 - 837 WP_227520814.1 hypothetical protein -
GQ627_RS27665 (GQ627_0ndm00333) 279606..279959 - 354 WP_004181774.1 hypothetical protein -
GQ627_RS27670 (GQ627_0ndm00334) 280104..281099 - 996 WP_046654939.1 hypothetical protein -
GQ627_RS27675 (GQ627_0ndm00335) 281433..283232 - 1800 WP_042935572.1 ATP-dependent helicase -
GQ627_RS27680 (GQ627_0ndm00336) 283523..283771 + 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GQ627_RS27685 (GQ627_0ndm00337) 283761..284045 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQ627_RS27690 (GQ627_0ndm00338) 284275..285501 + 1227 WP_042935575.1 RNA-guided endonuclease TnpB family protein -
GQ627_RS27695 (GQ627_0ndm00339) 285787..286212 - 426 WP_040120489.1 IS200/IS605 family transposase -
GQ627_RS27700 (GQ627_0ndm00340) 286249..287475 + 1227 WP_025368604.1 RNA-guided endonuclease TnpB family protein -
GQ627_RS27705 287541..288667 - 1127 Protein_315 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrE1 / aac(3)-IIa / blaTEM-1B / blaNDM-1 / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / catA1 - 1..372862 372862


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T199192 WP_004181778.1 NZ_CP072906:283761-284045 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T199192 NZ_CP097232:c1252003-1251901 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT199192 WP_025368601.1 NZ_CP072906:283523-283771 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT199192 NZ_CP097232:1251894-1252039 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References