Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4265368..4266025 Replicon chromosome
Accession NZ_CP072905
Organism Klebsiella pneumoniae strain COL17

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GQ627_RS20915 Protein ID WP_002916310.1
Coordinates 4265615..4266025 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GQ627_RS20910 Protein ID WP_002916312.1
Coordinates 4265368..4265634 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ627_RS20885 (4260524) 4260524..4261957 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
GQ627_RS20890 (4262076) 4262076..4262804 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GQ627_RS20895 (4262854) 4262854..4263165 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GQ627_RS20900 (4263329) 4263329..4263988 + 660 WP_002916317.1 hemolysin III family protein -
GQ627_RS20905 (4264139) 4264139..4265122 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
GQ627_RS20910 (4265368) 4265368..4265634 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GQ627_RS20915 (4265615) 4265615..4266025 + 411 WP_002916310.1 protein YgfX Toxin
GQ627_RS20920 (4266032) 4266032..4266553 - 522 WP_004144730.1 flavodoxin FldB -
GQ627_RS20925 (4266654) 4266654..4267550 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GQ627_RS20930 (4267573) 4267573..4268286 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GQ627_RS20935 (4268292) 4268292..4270025 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T199185 WP_002916310.1 NZ_CP072905:4265615-4266025 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T199185 NZ_CP097228:3936786-3937154 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT199185 WP_002916312.1 NZ_CP072905:4265368-4265634 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT199185 NZ_CP097228:3936568-3936789 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References