Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2857376..2857892 Replicon chromosome
Accession NZ_CP072905
Organism Klebsiella pneumoniae strain COL17

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag GQ627_RS13985 Protein ID WP_009486548.1
Coordinates 2857376..2857660 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GQ627_RS13990 Protein ID WP_002886901.1
Coordinates 2857650..2857892 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ627_RS13960 (2852793) 2852793..2853056 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
GQ627_RS13965 (2853186) 2853186..2853359 + 174 WP_032433782.1 hypothetical protein -
GQ627_RS13970 (2853362) 2853362..2854105 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GQ627_RS13975 (2854462) 2854462..2856600 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
GQ627_RS13980 (2856908) 2856908..2857372 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GQ627_RS13985 (2857376) 2857376..2857660 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQ627_RS13990 (2857650) 2857650..2857892 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GQ627_RS13995 (2857970) 2857970..2859880 - 1911 WP_009486549.1 PRD domain-containing protein -
GQ627_RS14000 (2859903) 2859903..2861057 - 1155 WP_002886900.1 lactonase family protein -
GQ627_RS14005 (2861124) 2861124..2861864 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T199180 WP_009486548.1 NZ_CP072905:c2857660-2857376 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T199180 NZ_CP072905:c2857660-2857376 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT199180 WP_002886901.1 NZ_CP072905:c2857892-2857650 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT199180 NZ_CP072905:c2857892-2857650 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References