199178

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2107134..2107753 Replicon chromosome
Accession NZ_CP072905
Organism Klebsiella pneumoniae strain COL17

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GQ627_RS10450 Protein ID WP_002892050.1
Coordinates 2107535..2107753 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GQ627_RS10445 Protein ID WP_002892066.1
Coordinates 2107134..2107508 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ627_RS10435 (2102286) 2102286..2103479 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GQ627_RS10440 (2103502) 2103502..2106648 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
GQ627_RS10445 (2107134) 2107134..2107508 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GQ627_RS10450 (2107535) 2107535..2107753 + 219 WP_002892050.1 HHA domain-containing protein Toxin
GQ627_RS10455 (2107916) 2107916..2108482 + 567 WP_002892030.1 maltose O-acetyltransferase -
GQ627_RS10460 (2108454) 2108454..2108594 - 141 WP_004147370.1 hypothetical protein -
GQ627_RS10465 (2108615) 2108615..2109085 + 471 WP_020802585.1 YlaC family protein -
GQ627_RS10470 (2109060) 2109060..2110511 - 1452 WP_004183206.1 PLP-dependent aminotransferase family protein -
GQ627_RS10475 (2110612) 2110612..2111310 + 699 WP_023287311.1 GNAT family protein -
GQ627_RS10480 (2111307) 2111307..2111447 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GQ627_RS10485 (2111447) 2111447..2111710 - 264 WP_032432663.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T199178 WP_002892050.1 NZ_CP072905:2107535-2107753 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T199178 NZ_CP097228:c1466550-1466448 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT199178 WP_002892066.1 NZ_CP072905:2107134-2107508 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT199178 NZ_CP097228:1466441-1466586 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References