Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1575254..1575846 | Replicon | chromosome |
| Accession | NZ_CP072904 | ||
| Organism | Bartonella henselae strain Marseille/ URLLY-8 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A829Z6B5 |
| Locus tag | KAE73_RS06800 | Protein ID | WP_034447446.1 |
| Coordinates | 1575646..1575846 (-) | Length | 67 a.a. |
Antitoxin (Protein)
| Gene name | hicA | Uniprot ID | A0A840E534 |
| Locus tag | KAE73_RS06795 | Protein ID | WP_011180290.1 |
| Coordinates | 1575254..1575649 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE73_RS06770 (KAE73_06650) | 1570997..1571542 | - | 546 | WP_236095365.1 | antA/AntB antirepressor family protein | - |
| KAE73_RS06775 (KAE73_06655) | 1571841..1572386 | - | 546 | Protein_1324 | antA/AntB antirepressor family protein | - |
| KAE73_RS06780 (KAE73_06660) | 1572961..1573551 | - | 591 | WP_038487063.1 | antA/AntB antirepressor family protein | - |
| KAE73_RS06785 (KAE73_06665) | 1573879..1574457 | - | 579 | WP_038487065.1 | hypothetical protein | - |
| KAE73_RS06790 (KAE73_06670) | 1574461..1574781 | - | 321 | WP_038487067.1 | hypothetical protein | - |
| KAE73_RS06795 (KAE73_06675) | 1575254..1575649 | - | 396 | WP_011180290.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KAE73_RS06800 (KAE73_06680) | 1575646..1575846 | - | 201 | WP_034447446.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KAE73_RS06805 (KAE73_06685) | 1575911..1576447 | - | 537 | WP_236095366.1 | hypothetical protein | - |
| KAE73_RS06810 (KAE73_06690) | 1576458..1576904 | - | 447 | WP_236095367.1 | single-stranded DNA-binding protein | - |
| KAE73_RS06815 | 1577095..1577250 | + | 156 | WP_236095368.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE73_RS06820 | 1577266..1577376 | + | 111 | Protein_1333 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE73_RS06825 (KAE73_06700) | 1577393..1577686 | + | 294 | WP_034447441.1 | HigA family addiction module antitoxin | - |
| KAE73_RS06830 (KAE73_06705) | 1577728..1578054 | - | 327 | WP_034447437.1 | hypothetical protein | - |
| KAE73_RS06835 (KAE73_06710) | 1578219..1578638 | - | 420 | WP_038525124.1 | hypothetical protein | - |
| KAE73_RS06840 (KAE73_06715) | 1578631..1579698 | - | 1068 | WP_038487076.1 | DUF1376 domain-containing protein | - |
| KAE73_RS06845 (KAE73_06720) | 1579688..1580032 | - | 345 | WP_034452646.1 | DUF1376 domain-containing protein | - |
| KAE73_RS06850 (KAE73_06725) | 1580022..1580504 | - | 483 | WP_208432304.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1522448..1593646 | 71198 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 67 a.a. Molecular weight: 7492.81 Da Isoelectric Point: 10.9914
>T199168 WP_034447446.1 NZ_CP072904:c1575846-1575646 [Bartonella henselae]
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
Download Length: 201 bp
>T199168 NZ_CP097223:c3036938-3036654 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14718.71 Da Isoelectric Point: 4.3191
>AT199168 WP_011180290.1 NZ_CP072904:c1575649-1575254 [Bartonella henselae]
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
Download Length: 396 bp
>AT199168 NZ_CP097223:c3037170-3036928 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829Z6B5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A840E534 |