Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-dinJ/YafQ-RelB |
| Location | 1569358..1569889 | Replicon | chromosome |
| Accession | NZ_CP072904 | ||
| Organism | Bartonella henselae strain Marseille/ URLLY-8 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | X5M5T9 |
| Locus tag | KAE73_RS06755 | Protein ID | WP_011180281.1 |
| Coordinates | 1569608..1569889 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | X5M3D1 |
| Locus tag | KAE73_RS06750 | Protein ID | WP_038487057.1 |
| Coordinates | 1569358..1569621 (+) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE73_RS06725 (KAE73_06605) | 1565494..1565742 | - | 249 | WP_038487052.1 | phage related protein | - |
| KAE73_RS06730 (KAE73_06610) | 1565746..1567677 | - | 1932 | WP_082251725.1 | phage terminase large subunit family protein | - |
| KAE73_RS06735 (KAE73_06615) | 1567708..1568259 | - | 552 | WP_034454327.1 | hypothetical protein | - |
| KAE73_RS06740 (KAE73_06620) | 1568322..1568636 | + | 315 | WP_038487056.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE73_RS06745 (KAE73_06625) | 1568653..1568949 | + | 297 | WP_034454130.1 | HigA family addiction module antitoxin | - |
| KAE73_RS06750 (KAE73_06630) | 1569358..1569621 | + | 264 | WP_038487057.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| KAE73_RS06755 (KAE73_06635) | 1569608..1569889 | + | 282 | WP_011180281.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| KAE73_RS06760 (KAE73_06640) | 1569932..1570210 | - | 279 | WP_038487059.1 | hypothetical protein | - |
| KAE73_RS06765 (KAE73_06645) | 1570207..1570965 | - | 759 | WP_038487061.1 | antA/AntB antirepressor family protein | - |
| KAE73_RS06770 (KAE73_06650) | 1570997..1571542 | - | 546 | WP_236095365.1 | antA/AntB antirepressor family protein | - |
| KAE73_RS06775 (KAE73_06655) | 1571841..1572386 | - | 546 | Protein_1324 | antA/AntB antirepressor family protein | - |
| KAE73_RS06780 (KAE73_06660) | 1572961..1573551 | - | 591 | WP_038487063.1 | antA/AntB antirepressor family protein | - |
| KAE73_RS06785 (KAE73_06665) | 1573879..1574457 | - | 579 | WP_038487065.1 | hypothetical protein | - |
| KAE73_RS06790 (KAE73_06670) | 1574461..1574781 | - | 321 | WP_038487067.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1522448..1593646 | 71198 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11106.85 Da Isoelectric Point: 10.3380
>T199167 WP_011180281.1 NZ_CP072904:1569608-1569889 [Bartonella henselae]
MRTIERTTIFKRDFKREMKGQHRHLLDTDLRKVIAALANDQPLEIRYRDHALTGNWSNYRDCHIRPDLVLIYRLIGQDRL
VLVRLGSHSQLDL
MRTIERTTIFKRDFKREMKGQHRHLLDTDLRKVIAALANDQPLEIRYRDHALTGNWSNYRDCHIRPDLVLIYRLIGQDRL
VLVRLGSHSQLDL
Download Length: 282 bp
>T199167 NZ_CP097223:c2926619-2926086 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9623.89 Da Isoelectric Point: 4.1403
>AT199167 WP_038487057.1 NZ_CP072904:1569358-1569621 [Bartonella henselae]
MATSRMVQARVPEEIQNVASQVIQASGLSVSDVVRVLMTRIAQDKAIPPFLFQPNAETIAAFAELDEGNLKKFHSVDELF
DDLYADD
MATSRMVQARVPEEIQNVASQVIQASGLSVSDVVRVLMTRIAQDKAIPPFLFQPNAETIAAFAELDEGNLKKFHSVDELF
DDLYADD
Download Length: 264 bp
>AT199167 NZ_CP097223:c2926896-2926630 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0R4J6H3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | X5M3D1 |