Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1535655..1536202 Replicon chromosome
Accession NZ_CP072904
Organism Bartonella henselae strain Marseille/ URLLY-8

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KAE73_RS06525 Protein ID WP_082251260.1
Coordinates 1535879..1536202 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KAE73_RS06520 Protein ID WP_019224016.1
Coordinates 1535655..1535879 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE73_RS06480 (KAE73_06365) 1532065..1532886 + 822 WP_236095359.1 antA/AntB antirepressor family protein -
KAE73_RS06485 (KAE73_06370) 1532914..1533462 + 549 WP_236095360.1 antA/AntB antirepressor family protein -
KAE73_RS06490 (KAE73_06375) 1533583..1533858 + 276 WP_011180235.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
KAE73_RS06495 (KAE73_06380) 1533871..1534161 + 291 WP_011180236.1 type II toxin-antitoxin system YafQ family toxin -
KAE73_RS06500 (KAE73_06385) 1534284..1534496 - 213 WP_034447463.1 hypothetical protein -
KAE73_RS06505 1534489..1534692 - 204 WP_034447462.1 hypothetical protein -
KAE73_RS06510 (KAE73_06390) 1534625..1534852 - 228 WP_038487030.1 hypothetical protein -
KAE73_RS06515 (KAE73_06395) 1534849..1535511 - 663 WP_236095361.1 lysozyme -
KAE73_RS06520 (KAE73_06400) 1535655..1535879 + 225 WP_019224016.1 antitoxin MazE family protein Antitoxin
KAE73_RS06525 (KAE73_06405) 1535879..1536202 + 324 WP_082251260.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KAE73_RS06530 (KAE73_06410) 1536248..1536403 + 156 Protein_1275 putative addiction module antidote protein -
KAE73_RS06535 (KAE73_06415) 1536453..1536731 - 279 WP_082251242.1 hypothetical protein -
KAE73_RS06540 (KAE73_06420) 1536728..1537456 - 729 WP_082251243.1 antA/AntB antirepressor family protein -
KAE73_RS06545 (KAE73_06425) 1537758..1538273 - 516 Protein_1278 Rha family transcriptional regulator -
KAE73_RS06550 (KAE73_06430) 1538584..1539891 - 1308 WP_082251245.1 contractile injection system protein, VgrG/Pvc8 family -
KAE73_RS06555 (KAE73_06435) 1539888..1540112 - 225 WP_011180247.1 tail protein X -
KAE73_RS06560 (KAE73_06440) 1540109..1540489 - 381 WP_011180248.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1522448..1593646 71198


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-102)

Antitoxin

Antitoxin MazE-like

(7-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11627.86 Da        Isoelectric Point: 10.3981

>T199165 WP_082251260.1 NZ_CP072904:1535879-1536202 [Bartonella henselae]
MRGSLVTIAMQGDFGKPRPALIIQANQFSEHTSVTVLPITSTLVAAPLLRITIQPNAKNGLQKPSQVMIDKIMTVRCEKV
SPAFGSIHADKMVEIERCLAVFLGIVK

Download         Length: 324 bp

>T199165 NZ_CP097223:c2207838-2207521 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8776.13 Da        Isoelectric Point: 8.5634

>AT199165 WP_019224016.1 NZ_CP072904:1535655-1535879 [Bartonella henselae]
MATMHVNERVQKHRNAQRKAGLRLMQIWVPDTRQPNFAEECRRQCRLVAKMDKTDTSMQLLMDQSLMDVDGWTE

Download         Length: 225 bp

>AT199165 NZ_CP097223:c2207528-2207241 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References