Detailed information of TA system TA199163

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 268477..269024
• Replicon: chromosome
• Accession: NZ_CP072904
• Organism: Bartonella henselae strain Marseille/ URLLY-8

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: KAE73_RS01305
• Protein ID: WP_082250412.1
• Coordinates: 268701..269024 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: X5M631
• Locus tag: KAE73_RS01300
• Protein ID: WP_038487033.1
• Coordinates: 268477..268701 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAE73_RS01270 (KAE73_01250)	266026..266271	-	246	WP_082251654.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KAE73_RS01275 (KAE73_01255)	266255..266482	-	228	WP_007346764.1	DUF6290 family protein	-
KAE73_RS01280 (KAE73_01260)	266590..266922	-	333	WP_011180620.1	type II toxin-antitoxin system PemK/MazF family toxin	-
KAE73_RS01285 (KAE73_01265)	266922..267179	-	258	WP_038487501.1	antitoxin	-
KAE73_RS01290 (KAE73_01270)	267260..267754	-	495	WP_038487773.1	hypothetical protein	-
KAE73_RS01295 (KAE73_01275)	267808..268254	-	447	WP_038487775.1	single-stranded DNA-binding protein	-
KAE73_RS01300 (KAE73_01280)	268477..268701	+	225	WP_038487033.1	antitoxin MazE family protein	Antitoxin
KAE73_RS01305 (KAE73_01285)	268701..269024	+	324	WP_082250412.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
KAE73_RS01310 (KAE73_01290)	269118..269417	+	300	WP_034448610.1	BrnT family toxin	-
KAE73_RS01315 (KAE73_01295)	269395..269700	+	306	WP_034448608.1	BrnA antitoxin family protein	-
KAE73_RS01320 (KAE73_01300)	269718..270011	+	294	WP_034447441.1	HigA family addiction module antitoxin	-
KAE73_RS01325 (KAE73_01305)	270053..270379	-	327	WP_082251643.1	hypothetical protein	-
KAE73_RS01330 (KAE73_01310)	270561..270947	-	387	WP_082246570.1	hypothetical protein	-
KAE73_RS01335 (KAE73_01315)	270931..272070	-	1140	WP_038487492.1	DUF1376 domain-containing protein	-
KAE73_RS01340 (KAE73_01320)	272060..272404	-	345	WP_034452646.1	DUF1376 domain-containing protein	-
KAE73_RS01345 (KAE73_01325)	272394..272876	-	483	WP_082251645.1	hypothetical protein	-
KAE73_RS01350 (KAE73_01330)	273013..273372	-	360	WP_011180610.1	hypothetical protein	-
KAE73_RS01355 (KAE73_01335)	273375..273638	-	264	WP_034448615.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	267808..307842	40034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-102)

Antitoxin

• Antitoxin MazE-like (7-72)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11779.04 Da
• Isoelectric Point: 9.3693

>T199163 WP_082250412.1 NZ_CP072904:268701-269024 [Bartonella henselae]
MRGSLVTIAMQGDFGKPRPALIIQANQFSEHTSVMVLPITSTLIDAPLLRITVQPDSKNGLQKPSQVMIDKIMTVRCEKV
SPAFGFIHADKMVEIERCLAVFLGIVK

Nucleotide

• Length: 324 bp

>T199163 NZ_CP097223:722613-723935 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCACCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8772.17 Da
• Isoelectric Point: 9.4438

>AT199163 WP_038487033.1 NZ_CP072904:268477-268701 [Bartonella henselae]
MATMHVNERVQKHRNAQRKAGLRLIQIWVPDTRQPNFAEECRRQCRLVAKMDKTDTSMQLLMDKSLMDIDGWTE

Nucleotide

• Length: 225 bp

>AT199163 NZ_CP097223:722347-722613 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: X5M631