Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-pasA/PRK09812-HTH
Location 266255..266922 Replicon chromosome
Accession NZ_CP072904
Organism Bartonella henselae strain Marseille/ URLLY-8

Toxin (Protein)


Gene name pemK Uniprot ID X5M710
Locus tag KAE73_RS01280 Protein ID WP_011180620.1
Coordinates 266590..266922 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID N6VJG4
Locus tag KAE73_RS01275 Protein ID WP_007346764.1
Coordinates 266255..266482 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE73_RS01270 (KAE73_01250) 266026..266271 - 246 WP_082251654.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAE73_RS01275 (KAE73_01255) 266255..266482 - 228 WP_007346764.1 DUF6290 family protein Antitoxin
KAE73_RS01280 (KAE73_01260) 266590..266922 - 333 WP_011180620.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KAE73_RS01285 (KAE73_01265) 266922..267179 - 258 WP_038487501.1 antitoxin -
KAE73_RS01290 (KAE73_01270) 267260..267754 - 495 WP_038487773.1 hypothetical protein -
KAE73_RS01295 (KAE73_01275) 267808..268254 - 447 WP_038487775.1 single-stranded DNA-binding protein -
KAE73_RS01300 (KAE73_01280) 268477..268701 + 225 WP_038487033.1 antitoxin MazE family protein -
KAE73_RS01305 (KAE73_01285) 268701..269024 + 324 WP_082250412.1 type II toxin-antitoxin system PemK/MazF family toxin -
KAE73_RS01310 (KAE73_01290) 269118..269417 + 300 WP_034448610.1 BrnT family toxin -
KAE73_RS01315 (KAE73_01295) 269395..269700 + 306 WP_034448608.1 BrnA antitoxin family protein -
KAE73_RS01320 (KAE73_01300) 269718..270011 + 294 WP_034447441.1 HigA family addiction module antitoxin -
KAE73_RS01325 (KAE73_01305) 270053..270379 - 327 WP_082251643.1 hypothetical protein -
KAE73_RS01330 (KAE73_01310) 270561..270947 - 387 WP_082246570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin

Protein of unknown function DUF6290

(2-71)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11865.88 Da        Isoelectric Point: 10.5590

>T199161 WP_011180620.1 NZ_CP072904:c266922-266590 [Bartonella henselae]
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT

Download         Length: 333 bp

>T199161 NZ_CP097221:c106786-106370 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8742.78 Da        Isoelectric Point: 4.8780

>AT199161 WP_007346764.1 NZ_CP072904:c266482-266255 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD

Download         Length: 228 bp

>AT199161 NZ_CP097221:c107013-106783 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A067W4K9

Antitoxin

Source ID Structure
AlphaFold DB N6VJG4

References