Detailed information of TA system TA199160

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 266026..266482
• Replicon: chromosome
• Accession: NZ_CP072904
• Organism: Bartonella henselae strain Marseille/ URLLY-8

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: KAE73_RS01270
• Protein ID: WP_082251654.1
• Coordinates: 266026..266271 (-)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: N6VJG4
• Locus tag: KAE73_RS01275
• Protein ID: WP_007346764.1
• Coordinates: 266255..266482 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAE73_RS01270 (KAE73_01250)	266026..266271	-	246	WP_082251654.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KAE73_RS01275 (KAE73_01255)	266255..266482	-	228	WP_007346764.1	DUF6290 family protein	Antitoxin
KAE73_RS01280 (KAE73_01260)	266590..266922	-	333	WP_011180620.1	type II toxin-antitoxin system PemK/MazF family toxin	-
KAE73_RS01285 (KAE73_01265)	266922..267179	-	258	WP_038487501.1	antitoxin	-
KAE73_RS01290 (KAE73_01270)	267260..267754	-	495	WP_038487773.1	hypothetical protein	-
KAE73_RS01295 (KAE73_01275)	267808..268254	-	447	WP_038487775.1	single-stranded DNA-binding protein	-
KAE73_RS01300 (KAE73_01280)	268477..268701	+	225	WP_038487033.1	antitoxin MazE family protein	-
KAE73_RS01305 (KAE73_01285)	268701..269024	+	324	WP_082250412.1	type II toxin-antitoxin system PemK/MazF family toxin	-
KAE73_RS01310 (KAE73_01290)	269118..269417	+	300	WP_034448610.1	BrnT family toxin	-
KAE73_RS01315 (KAE73_01295)	269395..269700	+	306	WP_034448608.1	BrnA antitoxin family protein	-
KAE73_RS01320 (KAE73_01300)	269718..270011	+	294	WP_034447441.1	HigA family addiction module antitoxin	-
KAE73_RS01325 (KAE73_01305)	270053..270379	-	327	WP_082251643.1	hypothetical protein	-
KAE73_RS01330 (KAE73_01310)	270561..270947	-	387	WP_082246570.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-72)

Antitoxin

• Protein of unknown function DUF6290 (2-71)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9520.32 Da
• Isoelectric Point: 9.5814

>T199160 WP_082251654.1 NZ_CP072904:c266271-266026 [Bartonella henselae]
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQFPGLWRYRVGDYRILCELVGVEILFLELQG
L

Nucleotide

• Length: 246 bp

>T199160 NZ_CP097221:c79439-78957 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8742.78 Da
• Isoelectric Point: 4.8780

>AT199160 WP_007346764.1 NZ_CP072904:c266482-266255 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD

Nucleotide

• Length: 228 bp

>AT199160 NZ_CP097221:c79708-79430 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Structures

Antitoxin

• AlphaFold DB: N6VJG4