Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-pasA/PRK09812-HTH
Location 172297..172964 Replicon chromosome
Accession NZ_CP072904
Organism Bartonella henselae strain Marseille/ URLLY-8

Toxin (Protein)


Gene name pemK Uniprot ID X5M710
Locus tag KAE73_RS00865 Protein ID WP_011180620.1
Coordinates 172632..172964 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID N6VJG4
Locus tag KAE73_RS00860 Protein ID WP_007346764.1
Coordinates 172297..172524 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE73_RS00830 (KAE73_00825) 168371..168571 + 201 WP_034454877.1 DNA-binding protein -
KAE73_RS00835 (KAE73_00830) 168644..169525 + 882 WP_038487768.1 toprim domain-containing protein -
KAE73_RS00840 (KAE73_00835) 169623..170426 - 804 Protein_161 phage terminase large subunit -
KAE73_RS00845 (KAE73_00840) 170407..170733 - 327 WP_051524333.1 hypothetical protein -
KAE73_RS00850 (KAE73_00845) 171580..172014 + 435 WP_038487438.1 hypothetical protein -
KAE73_RS00855 (KAE73_00850) 172044..172313 - 270 WP_038487435.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAE73_RS00860 (KAE73_00855) 172297..172524 - 228 WP_007346764.1 DUF6290 family protein Antitoxin
KAE73_RS00865 (KAE73_00860) 172632..172964 - 333 WP_011180620.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KAE73_RS00870 (KAE73_00865) 172964..173221 - 258 WP_038487501.1 antitoxin -
KAE73_RS00875 (KAE73_00870) 173302..173814 - 513 WP_172642310.1 hypothetical protein -
KAE73_RS00880 (KAE73_00875) 173870..174316 - 447 WP_038487497.1 single-stranded DNA-binding protein -
KAE73_RS00885 (KAE73_00880) 174539..174763 + 225 WP_038487033.1 antitoxin MazE family protein -
KAE73_RS00890 (KAE73_00885) 174763..175086 + 324 WP_082250412.1 type II toxin-antitoxin system PemK/MazF family toxin -
KAE73_RS00895 (KAE73_00890) 175180..175479 + 300 WP_034448610.1 BrnT family toxin -
KAE73_RS00900 (KAE73_00895) 175457..175762 + 306 WP_082250408.1 BrnA antitoxin family protein -
KAE73_RS00905 (KAE73_00900) 175836..176264 + 429 WP_082250409.1 type II toxin-antitoxin system HicB family antitoxin -
KAE73_RS00910 176382..176895 - 514 Protein_175 hypothetical protein -
KAE73_RS00915 (KAE73_00905) 176939..177274 - 336 WP_082250410.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin

Protein of unknown function DUF6290

(2-71)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11865.88 Da        Isoelectric Point: 10.5590

>T199157 WP_011180620.1 NZ_CP072904:c172964-172632 [Bartonella henselae]
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT

Download         Length: 333 bp

>T199157 NZ_CP097220:4749077-4749994 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCATCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8742.78 Da        Isoelectric Point: 4.8780

>AT199157 WP_007346764.1 NZ_CP072904:c172524-172297 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD

Download         Length: 228 bp

>AT199157 NZ_CP097220:4748313-4749071 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A067W4K9

Antitoxin

Source ID Structure
AlphaFold DB N6VJG4

References