Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 172044..172524 | Replicon | chromosome |
| Accession | NZ_CP072904 | ||
| Organism | Bartonella henselae strain Marseille/ URLLY-8 | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | X5LZS8 |
| Locus tag | KAE73_RS00855 | Protein ID | WP_038487435.1 |
| Coordinates | 172044..172313 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | N6VJG4 |
| Locus tag | KAE73_RS00860 | Protein ID | WP_007346764.1 |
| Coordinates | 172297..172524 (-) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE73_RS00830 (KAE73_00825) | 168371..168571 | + | 201 | WP_034454877.1 | DNA-binding protein | - |
| KAE73_RS00835 (KAE73_00830) | 168644..169525 | + | 882 | WP_038487768.1 | toprim domain-containing protein | - |
| KAE73_RS00840 (KAE73_00835) | 169623..170426 | - | 804 | Protein_161 | phage terminase large subunit | - |
| KAE73_RS00845 (KAE73_00840) | 170407..170733 | - | 327 | WP_051524333.1 | hypothetical protein | - |
| KAE73_RS00850 (KAE73_00845) | 171580..172014 | + | 435 | WP_038487438.1 | hypothetical protein | - |
| KAE73_RS00855 (KAE73_00850) | 172044..172313 | - | 270 | WP_038487435.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KAE73_RS00860 (KAE73_00855) | 172297..172524 | - | 228 | WP_007346764.1 | DUF6290 family protein | Antitoxin |
| KAE73_RS00865 (KAE73_00860) | 172632..172964 | - | 333 | WP_011180620.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| KAE73_RS00870 (KAE73_00865) | 172964..173221 | - | 258 | WP_038487501.1 | antitoxin | - |
| KAE73_RS00875 (KAE73_00870) | 173302..173814 | - | 513 | WP_172642310.1 | hypothetical protein | - |
| KAE73_RS00880 (KAE73_00875) | 173870..174316 | - | 447 | WP_038487497.1 | single-stranded DNA-binding protein | - |
| KAE73_RS00885 (KAE73_00880) | 174539..174763 | + | 225 | WP_038487033.1 | antitoxin MazE family protein | - |
| KAE73_RS00890 (KAE73_00885) | 174763..175086 | + | 324 | WP_082250412.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| KAE73_RS00895 (KAE73_00890) | 175180..175479 | + | 300 | WP_034448610.1 | BrnT family toxin | - |
| KAE73_RS00900 (KAE73_00895) | 175457..175762 | + | 306 | WP_082250408.1 | BrnA antitoxin family protein | - |
| KAE73_RS00905 (KAE73_00900) | 175836..176264 | + | 429 | WP_082250409.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| KAE73_RS00910 | 176382..176895 | - | 514 | Protein_175 | hypothetical protein | - |
| KAE73_RS00915 (KAE73_00905) | 176939..177274 | - | 336 | WP_082250410.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10505.48 Da Isoelectric Point: 10.2009
>T199156 WP_038487435.1 NZ_CP072904:c172313-172044 [Bartonella henselae]
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQFPGLWRYRVGDYRILCELYDKELVVLVLAV
GHRKNIYKG
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQFPGLWRYRVGDYRILCELYDKELVVLVLAV
GHRKNIYKG
Download Length: 270 bp
>T199156 NZ_CP097220:4436854-4437237 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8742.78 Da Isoelectric Point: 4.8780
>AT199156 WP_007346764.1 NZ_CP072904:c172524-172297 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD
Download Length: 228 bp
>AT199156 NZ_CP097220:4436612-4436854 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|