Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-parD/RelE-RHH |
| Location | 50881..51440 | Replicon | chromosome |
| Accession | NZ_CP072904 | ||
| Organism | Bartonella henselae strain Marseille/ URLLY-8 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | X5M706 |
| Locus tag | KAE73_RS00265 | Protein ID | WP_011180615.1 |
| Coordinates | 51168..51440 (+) | Length | 91 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | X5M4C9 |
| Locus tag | KAE73_RS00260 | Protein ID | WP_038487495.1 |
| Coordinates | 50881..51171 (+) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE73_RS00205 (KAE73_00210) | 46127..46406 | + | 280 | Protein_38 | type II toxin-antitoxin system YafQ family toxin | - |
| KAE73_RS00210 (KAE73_00215) | 46529..46741 | - | 213 | WP_034447463.1 | hypothetical protein | - |
| KAE73_RS00215 | 46734..46937 | - | 204 | WP_082251385.1 | hypothetical protein | - |
| KAE73_RS00220 (KAE73_00220) | 46870..47096 | - | 227 | Protein_41 | hypothetical protein | - |
| KAE73_RS00225 (KAE73_00225) | 47093..47755 | - | 663 | WP_236095375.1 | lysozyme | - |
| KAE73_RS00230 (KAE73_00230) | 47862..48185 | + | 324 | WP_082250455.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE73_RS00235 (KAE73_00235) | 48197..48490 | + | 294 | WP_082250456.1 | addiction module antidote protein | - |
| KAE73_RS00240 (KAE73_00240) | 48561..48839 | - | 279 | WP_082250457.1 | hypothetical protein | - |
| KAE73_RS00245 (KAE73_00245) | 48836..49585 | - | 750 | WP_082250458.1 | antA/AntB antirepressor family protein | - |
| KAE73_RS00250 (KAE73_00250) | 49582..50157 | - | 576 | WP_236095376.1 | hypothetical protein | - |
| KAE73_RS00255 (KAE73_00255) | 50213..50659 | - | 447 | WP_038487497.1 | single-stranded DNA-binding protein | - |
| KAE73_RS00260 (KAE73_00260) | 50881..51171 | + | 291 | WP_038487495.1 | hypothetical protein | Antitoxin |
| KAE73_RS00265 (KAE73_00265) | 51168..51440 | + | 273 | WP_011180615.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| KAE73_RS00270 | 51631..51947 | - | 317 | Protein_51 | hypothetical protein | - |
| KAE73_RS00275 (KAE73_00275) | 52129..52515 | - | 387 | WP_082246570.1 | hypothetical protein | - |
| KAE73_RS00280 (KAE73_00280) | 52499..53638 | - | 1140 | WP_038487492.1 | DUF1376 domain-containing protein | - |
| KAE73_RS00285 (KAE73_00285) | 53628..53972 | - | 345 | WP_034452646.1 | DUF1376 domain-containing protein | - |
| KAE73_RS00290 (KAE73_00290) | 53962..54444 | - | 483 | WP_038487489.1 | phage related protein | - |
| KAE73_RS00295 (KAE73_00295) | 54572..55342 | + | 771 | WP_236095377.1 | hypothetical protein | - |
| KAE73_RS00300 (KAE73_00300) | 55360..55725 | - | 366 | WP_038488832.1 | hypothetical protein | - |
| KAE73_RS00305 | 56002..56190 | - | 189 | WP_038487081.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 34533..60105 | 25572 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10747.75 Da Isoelectric Point: 11.3976
>T199155 WP_011180615.1 NZ_CP072904:51168-51440 [Bartonella henselae]
MKLVWTRIAHYDRQKIREYIAQENPSAALVFDKLLSKKVERLISFPNLGRVGRIRNTRELIVRKNYIMIYDVSNGTIRVL
RILHAKQKWP
MKLVWTRIAHYDRQKIREYIAQENPSAALVFDKLLSKKVERLISFPNLGRVGRIRNTRELIVRKNYIMIYDVSNGTIRVL
RILHAKQKWP
Download Length: 273 bp
>T199155 NZ_CP097220:c3999823-3999455 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 11155.54 Da Isoelectric Point: 4.7370
>AT199155 WP_038487495.1 NZ_CP072904:50881-51171 [Bartonella henselae]
MAETTFTFRVDDVLKSEFSRAAKACDRSAAQLLRDYMRDIVKEQKEKIAHELWFQEQVQLGLNSANAGDVIPFEEIETEA
QAWRFEIQRKLKTSDS
MAETTFTFRVDDVLKSEFSRAAKACDRSAAQLLRDYMRDIVKEQKEKIAHELWFQEQVQLGLNSANAGDVIPFEEIETEA
QAWRFEIQRKLKTSDS
Download Length: 291 bp
>AT199155 NZ_CP097220:c4000041-3999820 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067W4L5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | X5M4C9 |