Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 40439..41013 Replicon chromosome
Accession NZ_CP072904
Organism Bartonella henselae strain Marseille/ URLLY-8

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KAE73_RS00170 Protein ID WP_082250436.1
Coordinates 40723..41013 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag KAE73_RS00165 Protein ID WP_082250437.1
Coordinates 40439..40723 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE73_RS00120 (KAE73_00125) 35863..36322 - 460 Protein_21 transcriptional regulator -
KAE73_RS00125 (KAE73_00130) 36520..36811 + 292 Protein_22 helix-turn-helix domain-containing protein -
KAE73_RS00130 (KAE73_00135) 36886..37029 + 144 WP_180372114.1 hypothetical protein -
KAE73_RS00135 (KAE73_00140) 37037..37369 + 333 WP_236095411.1 hypothetical protein -
KAE73_RS00140 (KAE73_00145) 37369..38251 + 883 Protein_25 ParB/RepB/Spo0J family partition protein -
KAE73_RS00145 38572..38837 + 266 Protein_26 DUF5664 domain-containing protein -
KAE73_RS00150 (KAE73_00150) 38824..39111 + 288 WP_038488880.1 hypothetical protein -
KAE73_RS00155 39355..39828 + 474 Protein_28 hypothetical protein -
KAE73_RS00160 (KAE73_00165) 40202..40402 + 201 WP_082250438.1 hypothetical protein -
KAE73_RS00165 (KAE73_00170) 40439..40723 - 285 WP_082250437.1 putative addiction module antidote protein Antitoxin
KAE73_RS00170 (KAE73_00175) 40723..41013 - 291 WP_082250436.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KAE73_RS00175 41329..41718 + 390 WP_236095373.1 hypothetical protein -
KAE73_RS00180 (KAE73_00185) 41782..42684 + 903 Protein_33 hypothetical protein -
KAE73_RS00185 (KAE73_00190) 42890..44047 + 1158 WP_082250435.1 integrase arm-type DNA-binding domain-containing protein -
KAE73_RS00190 (KAE73_00195) 44318..45142 + 825 WP_236095374.1 antA/AntB antirepressor family protein -
KAE73_RS00195 (KAE73_00200) 45170..45718 + 549 WP_082250434.1 antA/AntB antirepressor family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 34533..60105 25572


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-94)

Antitoxin

Uncharacterized protein HI1420

(5-89)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11256.13 Da        Isoelectric Point: 10.0364

>T199154 WP_082250436.1 NZ_CP072904:c41013-40723 [Bartonella henselae]
MVIIRKTREFDTWLEKLKDKSVKTIILQRVARLRQGLLGDVKFFNNIGELRIHYGAGYRIHFTQEGSEFILLLCGGDKST
QKKDIEQALKLKEEYQ

Download         Length: 291 bp

>T199154 NZ_CP097220:c3530826-3530416 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGAAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10284.66 Da        Isoelectric Point: 5.0644

>AT199154 WP_082250437.1 NZ_CP072904:c40723-40439 [Bartonella henselae]
MKATLFKPEEYLETPEEQQMFLNEAFKTGDAAHIADAIGIVARAQNMSALARTTDRERSGLYRSLSKDGDPKLSTLVAVL
SALNLQLNVQSSIS

Download         Length: 285 bp

>AT199154 NZ_CP097220:c3531073-3530807 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References