Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1623013..1623605 Replicon chromosome
Accession NZ_CP072903
Organism Bartonella henselae strain ATCC49882T var-1/ Houston-I

Toxin (Protein)


Gene name hicA Uniprot ID A0A829Z6B5
Locus tag KAE76_RS06820 Protein ID WP_034447446.1
Coordinates 1623405..1623605 (-) Length 67 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID A0A840E534
Locus tag KAE76_RS06815 Protein ID WP_011180290.1
Coordinates 1623013..1623408 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE76_RS06785 (KAE76_06680) 1618278..1619036 - 759 WP_011180282.1 phage antirepressor Ant -
KAE76_RS06790 (KAE76_06685) 1619096..1619611 - 516 WP_011180283.1 phage antirepressor Ant -
KAE76_RS06795 (KAE76_06690) 1619628..1620467 - 840 WP_011180284.1 antA/AntB antirepressor family protein -
KAE76_RS06800 (KAE76_06695) 1620499..1621041 - 543 WP_011180285.1 phage antirepressor Ant -
KAE76_RS06805 (KAE76_06700) 1621638..1622216 - 579 WP_011180287.1 hypothetical protein -
KAE76_RS06810 (KAE76_06705) 1622220..1622540 - 321 WP_011180288.1 hypothetical protein -
KAE76_RS06815 (KAE76_06710) 1623013..1623408 - 396 WP_011180290.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KAE76_RS06820 (KAE76_06715) 1623405..1623605 - 201 WP_034447446.1 type II toxin-antitoxin system HicA family toxin Toxin
KAE76_RS06825 (KAE76_06720) 1623670..1624206 - 537 WP_034447444.1 hypothetical protein -
KAE76_RS06830 (KAE76_06725) 1624217..1624663 - 447 WP_011180293.1 single-stranded DNA-binding protein -
KAE76_RS06835 (KAE76_06730) 1624854..1625135 + 282 WP_011180826.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAE76_RS06840 (KAE76_06735) 1625152..1625445 + 294 WP_034447441.1 HigA family addiction module antitoxin -
KAE76_RS06845 (KAE76_06740) 1625487..1625813 - 327 WP_034447437.1 hypothetical protein -
KAE76_RS06850 (KAE76_06745) 1625978..1626397 - 420 WP_038525124.1 hypothetical protein -
KAE76_RS06855 (KAE76_06750) 1626390..1627502 - 1113 WP_011180297.1 DUF1376 domain-containing protein -
KAE76_RS06860 (KAE76_06755) 1627492..1627839 - 348 WP_011180298.1 DUF1376 domain-containing protein -
KAE76_RS06865 (KAE76_06760) 1627832..1628308 - 477 WP_011180299.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1572665..1642326 69661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-125)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7492.81 Da        Isoelectric Point: 10.9914

>T199153 WP_034447446.1 NZ_CP072903:c1623605-1623405 [Bartonella henselae]
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE

Download         Length: 201 bp

>T199153 NZ_CP097220:c1874557-1873235 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCACCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14718.71 Da        Isoelectric Point: 4.3191

>AT199153 WP_011180290.1 NZ_CP072903:c1623408-1623013 [Bartonella henselae]
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI

Download         Length: 396 bp

>AT199153 NZ_CP097220:c1874823-1874557 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829Z6B5

Antitoxin

Source ID Structure
AlphaFold DB A0A840E534

References