Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 1617429..1617960 Replicon chromosome
Accession NZ_CP072903
Organism Bartonella henselae strain ATCC49882T var-1/ Houston-I

Toxin (Protein)


Gene name relE Uniprot ID X5M5T9
Locus tag KAE76_RS06775 Protein ID WP_011180281.1
Coordinates 1617679..1617960 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A0H3LWD6
Locus tag KAE76_RS06770 Protein ID WP_011180280.1
Coordinates 1617429..1617692 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE76_RS06745 (KAE76_06640) 1613575..1613823 - 249 WP_011180274.1 hypothetical protein -
KAE76_RS06750 (KAE76_06645) 1613827..1615755 - 1929 WP_011180275.1 phage terminase large subunit family protein -
KAE76_RS06755 (KAE76_06650) 1615748..1616329 - 582 WP_011180276.1 hypothetical protein -
KAE76_RS06760 (KAE76_06655) 1616392..1616706 + 315 WP_011180277.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAE76_RS06765 (KAE76_06660) 1616723..1617019 + 297 WP_011180278.1 HigA family addiction module antitoxin -
KAE76_RS06770 (KAE76_06665) 1617429..1617692 + 264 WP_011180280.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KAE76_RS06775 (KAE76_06670) 1617679..1617960 + 282 WP_011180281.1 type II toxin-antitoxin system YafQ family toxin Toxin
KAE76_RS06780 (KAE76_06675) 1618003..1618281 - 279 WP_011180242.1 hypothetical protein -
KAE76_RS06785 (KAE76_06680) 1618278..1619036 - 759 WP_011180282.1 phage antirepressor Ant -
KAE76_RS06790 (KAE76_06685) 1619096..1619611 - 516 WP_011180283.1 phage antirepressor Ant -
KAE76_RS06795 (KAE76_06690) 1619628..1620467 - 840 WP_011180284.1 antA/AntB antirepressor family protein -
KAE76_RS06800 (KAE76_06695) 1620499..1621041 - 543 WP_011180285.1 phage antirepressor Ant -
KAE76_RS06805 (KAE76_06700) 1621638..1622216 - 579 WP_011180287.1 hypothetical protein -
KAE76_RS06810 (KAE76_06705) 1622220..1622540 - 321 WP_011180288.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1572665..1642326 69661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-82)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11106.85 Da        Isoelectric Point: 10.3380

>T199152 WP_011180281.1 NZ_CP072903:1617679-1617960 [Bartonella henselae]
MRTIERTTIFKRDFKREMKGQHRHLLDTDLRKVIAALANDQPLEIRYRDHALTGNWSNYRDCHIRPDLVLIYRLIGQDRL
VLVRLGSHSQLDL

Download         Length: 282 bp

>T199152 NZ_CP097220:1124883-1124985 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9565.81 Da        Isoelectric Point: 4.1403

>AT199152 WP_011180280.1 NZ_CP072903:1617429-1617692 [Bartonella henselae]
MATSRMVQARVPEEIQNVASQVIQASGLTVSDVVRVLMTRIAQDKAIPSVLFQPNAETIAAFAEVDEGNLKKFHSVDELF
DDLYADD

Download         Length: 264 bp

>AT199152 NZ_CP097220:c1124992-1124847 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R4J6H3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LWD6

References