Detailed information of TA system TA199150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 296268..296747
• Replicon: chromosome
• Accession: NZ_CP072903
• Organism: Bartonella henselae strain ATCC49882T var-1/ Houston-I

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KAE76_RS01425
• Protein ID: WP_236087019.1
• Coordinates: 296268..296420 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A829YZI5
• Locus tag: KAE76_RS01430
• Protein ID: WP_034447857.1
• Coordinates: 296520..296747 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAE76_RS01405 (KAE76_01395)	293547..294686	-	1140	WP_049784545.1	phage terminase large subunit	-
KAE76_RS01410 (KAE76_01400)	294667..294993	-	327	WP_011180626.1	hypothetical protein	-
KAE76_RS01415 (KAE76_01405)	295292..295750	+	459	WP_011180624.1	hypothetical protein	-
KAE76_RS01420	295846..296238	+	393	WP_223396448.1	hypothetical protein	-
KAE76_RS01425	296268..296420	-	153	WP_236087019.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KAE76_RS01430 (KAE76_01415)	296520..296747	-	228	WP_034447857.1	DUF6290 family protein	Antitoxin
KAE76_RS01435 (KAE76_01420)	296844..297338	-	495	WP_011180825.1	hypothetical protein	-
KAE76_RS01440 (KAE76_01425)	297392..297838	-	447	WP_011180617.1	single-stranded DNA-binding protein	-
KAE76_RS01445 (KAE76_01430)	298029..298310	+	282	WP_011180826.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KAE76_RS01450 (KAE76_01435)	298327..298620	+	294	WP_034447441.1	HigA family addiction module antitoxin	-
KAE76_RS01455 (KAE76_01440)	298662..298988	-	327	WP_011180827.1	hypothetical protein	-
KAE76_RS01465 (KAE76_01450)	299563..299868	-	306	WP_011180828.1	ETC complex I subunit	-
KAE76_RS01475 (KAE76_01460)	300862..301551	-	690	WP_011180829.1	DnaA regulatory inactivator HdaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-48)

Antitoxin

• Protein of unknown function DUF6290 (2-71)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5819.95 Da
• Isoelectric Point: 10.3747

>T199150 WP_236087019.1 NZ_CP072903:c296420-296268 [Bartonella henselae]
VRVIGKPLKGQFSGLWRYRVGDYRILCELYDKELVVLVLAVGHRKNIYKG

Nucleotide

• Length: 153 bp

>T199150 NZ_CP097220:c264058-263840 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8714.77 Da
• Isoelectric Point: 4.8780

>AT199150 WP_034447857.1 NZ_CP072903:c296747-296520 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRKGEGTFYSSEEVRKELGLDD

Nucleotide

• Length: 228 bp

>AT199150 NZ_CP097220:c264459-264085 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A829YZI5