Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
| Location | 262419..263008 | Replicon | chromosome |
| Accession | NZ_CP072903 | ||
| Organism | Bartonella henselae strain ATCC49882T var-1/ Houston-I | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | X5M710 |
| Locus tag | KAE76_RS01215 | Protein ID | WP_011180620.1 |
| Coordinates | 262419..262751 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | A0A829Z4P4 |
| Locus tag | KAE76_RS01220 | Protein ID | WP_034448603.1 |
| Coordinates | 262751..263008 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE76_RS01185 (KAE76_01170) | 258924..260249 | - | 1326 | WP_011180823.1 | phage terminase large subunit | - |
| KAE76_RS01190 (KAE76_01175) | 260230..260556 | - | 327 | WP_011180626.1 | hypothetical protein | - |
| KAE76_RS01195 (KAE76_01180) | 260855..261313 | + | 459 | WP_011180624.1 | hypothetical protein | - |
| KAE76_RS01200 | 261409..261801 | + | 393 | WP_075320637.1 | hypothetical protein | - |
| KAE76_RS01205 (KAE76_01185) | 261831..262100 | - | 270 | WP_011180622.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE76_RS01210 (KAE76_01190) | 262084..262311 | - | 228 | WP_007346764.1 | DUF6290 family protein | - |
| KAE76_RS01215 (KAE76_01195) | 262419..262751 | - | 333 | WP_011180620.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| KAE76_RS01220 (KAE76_01200) | 262751..263008 | - | 258 | WP_034448603.1 | antitoxin | Antitoxin |
| KAE76_RS01225 (KAE76_01205) | 263089..263583 | - | 495 | WP_059443338.1 | hypothetical protein | - |
| KAE76_RS01230 (KAE76_01210) | 263637..264083 | - | 447 | WP_011180617.1 | single-stranded DNA-binding protein | - |
| KAE76_RS01235 (KAE76_01215) | 264295..264585 | + | 291 | WP_011180616.1 | hypothetical protein | - |
| KAE76_RS01240 (KAE76_01220) | 264582..264854 | + | 273 | WP_011180615.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| KAE76_RS01245 (KAE76_01225) | 265045..265362 | - | 318 | Protein_239 | hypothetical protein | - |
| KAE76_RS01250 (KAE76_01230) | 265544..265930 | - | 387 | WP_082246570.1 | hypothetical protein | - |
| KAE76_RS01255 (KAE76_01235) | 265914..267164 | - | 1251 | WP_011180612.1 | DUF1376 domain-containing protein | - |
| KAE76_RS01260 (KAE76_01240) | 267154..267633 | - | 480 | WP_011180611.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 235926..276048 | 40122 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11865.88 Da Isoelectric Point: 10.5590
>T199148 WP_011180620.1 NZ_CP072903:c262751-262419 [Bartonella henselae]
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT
Download Length: 333 bp
>T199148 NZ_CP097214:103949-104365 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9381.71 Da Isoelectric Point: 4.2101
>AT199148 WP_034448603.1 NZ_CP072903:c263008-262751 [Bartonella henselae]
MHTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLVVKPQTFPSYTLDELLAQCNPSDDFADEDMEWFDAKPV
GRELL
MHTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLVVKPQTFPSYTLDELLAQCNPSDDFADEDMEWFDAKPV
GRELL
Download Length: 258 bp
>AT199148 NZ_CP097214:103722-103952 [Escherichia coli]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067W4K9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829Z4P4 |