Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-pasA/PRK09812-HTH
Location 262084..262751 Replicon chromosome
Accession NZ_CP072903
Organism Bartonella henselae strain ATCC49882T var-1/ Houston-I

Toxin (Protein)


Gene name pemK Uniprot ID X5M710
Locus tag KAE76_RS01215 Protein ID WP_011180620.1
Coordinates 262419..262751 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID N6VJG4
Locus tag KAE76_RS01210 Protein ID WP_007346764.1
Coordinates 262084..262311 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE76_RS01185 (KAE76_01170) 258924..260249 - 1326 WP_011180823.1 phage terminase large subunit -
KAE76_RS01190 (KAE76_01175) 260230..260556 - 327 WP_011180626.1 hypothetical protein -
KAE76_RS01195 (KAE76_01180) 260855..261313 + 459 WP_011180624.1 hypothetical protein -
KAE76_RS01200 261409..261801 + 393 WP_075320637.1 hypothetical protein -
KAE76_RS01205 (KAE76_01185) 261831..262100 - 270 WP_011180622.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAE76_RS01210 (KAE76_01190) 262084..262311 - 228 WP_007346764.1 DUF6290 family protein Antitoxin
KAE76_RS01215 (KAE76_01195) 262419..262751 - 333 WP_011180620.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KAE76_RS01220 (KAE76_01200) 262751..263008 - 258 WP_034448603.1 antitoxin -
KAE76_RS01225 (KAE76_01205) 263089..263583 - 495 WP_059443338.1 hypothetical protein -
KAE76_RS01230 (KAE76_01210) 263637..264083 - 447 WP_011180617.1 single-stranded DNA-binding protein -
KAE76_RS01235 (KAE76_01215) 264295..264585 + 291 WP_011180616.1 hypothetical protein -
KAE76_RS01240 (KAE76_01220) 264582..264854 + 273 WP_011180615.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
KAE76_RS01245 (KAE76_01225) 265045..265362 - 318 Protein_239 hypothetical protein -
KAE76_RS01250 (KAE76_01230) 265544..265930 - 387 WP_082246570.1 hypothetical protein -
KAE76_RS01255 (KAE76_01235) 265914..267164 - 1251 WP_011180612.1 DUF1376 domain-containing protein -
KAE76_RS01260 (KAE76_01240) 267154..267633 - 480 WP_011180611.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 235926..276048 40122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin

Protein of unknown function DUF6290

(2-71)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11865.88 Da        Isoelectric Point: 10.5590

>T199147 WP_011180620.1 NZ_CP072903:c262751-262419 [Bartonella henselae]
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT

Download         Length: 333 bp

>T199147 NZ_CP097214:86259-86408 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8742.78 Da        Isoelectric Point: 4.8780

>AT199147 WP_007346764.1 NZ_CP072903:c262311-262084 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD

Download         Length: 228 bp

>AT199147 NZ_CP097214:c86215-86154 [Escherichia coli]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A067W4K9

Antitoxin

Source ID Structure
AlphaFold DB N6VJG4

References