Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1599138..1599730 | Replicon | chromosome |
| Accession | NZ_CP072902 | ||
| Organism | Bartonella henselae strain ATCC49882T var-2/ Houston-I | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A829Z6B5 |
| Locus tag | KAE74_RS06885 | Protein ID | WP_034447446.1 |
| Coordinates | 1599530..1599730 (-) | Length | 67 a.a. |
Antitoxin (Protein)
| Gene name | hicA | Uniprot ID | A0A840E534 |
| Locus tag | KAE74_RS06880 | Protein ID | WP_011180290.1 |
| Coordinates | 1599138..1599533 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE74_RS06850 (KAE74_06700) | 1594403..1595161 | - | 759 | WP_011180282.1 | phage antirepressor Ant | - |
| KAE74_RS06855 (KAE74_06705) | 1595221..1595736 | - | 516 | WP_011180283.1 | phage antirepressor Ant | - |
| KAE74_RS06860 (KAE74_06710) | 1595753..1596592 | - | 840 | WP_011180284.1 | antA/AntB antirepressor family protein | - |
| KAE74_RS06865 (KAE74_06715) | 1596624..1597166 | - | 543 | WP_011180285.1 | phage antirepressor Ant | - |
| KAE74_RS06870 (KAE74_06720) | 1597763..1598341 | - | 579 | WP_011180287.1 | hypothetical protein | - |
| KAE74_RS06875 (KAE74_06725) | 1598345..1598665 | - | 321 | WP_011180288.1 | hypothetical protein | - |
| KAE74_RS06880 (KAE74_06730) | 1599138..1599533 | - | 396 | WP_011180290.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KAE74_RS06885 (KAE74_06735) | 1599530..1599730 | - | 201 | WP_034447446.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KAE74_RS06890 (KAE74_06740) | 1599795..1600331 | - | 537 | WP_034447444.1 | hypothetical protein | - |
| KAE74_RS06895 (KAE74_06745) | 1600342..1600788 | - | 447 | WP_011180293.1 | single-stranded DNA-binding protein | - |
| KAE74_RS06900 (KAE74_06750) | 1600979..1601260 | + | 282 | WP_011180826.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE74_RS06905 (KAE74_06755) | 1601277..1601570 | + | 294 | WP_034447441.1 | HigA family addiction module antitoxin | - |
| KAE74_RS06910 (KAE74_06760) | 1601612..1601938 | - | 327 | WP_034447437.1 | hypothetical protein | - |
| KAE74_RS06915 (KAE74_06765) | 1602103..1602522 | - | 420 | WP_038525124.1 | hypothetical protein | - |
| KAE74_RS06920 (KAE74_06770) | 1602515..1603627 | - | 1113 | WP_011180297.1 | DUF1376 domain-containing protein | - |
| KAE74_RS06925 (KAE74_06775) | 1603617..1603964 | - | 348 | WP_011180298.1 | DUF1376 domain-containing protein | - |
| KAE74_RS06930 (KAE74_06780) | 1603957..1604433 | - | 477 | WP_011180299.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1551243..1618451 | 67208 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 67 a.a. Molecular weight: 7492.81 Da Isoelectric Point: 10.9914
>T199145 WP_034447446.1 NZ_CP072902:c1599730-1599530 [Bartonella henselae]
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
Download Length: 201 bp
>T199145 NZ_CP097214:29323-29628 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14718.71 Da Isoelectric Point: 4.3191
>AT199145 WP_011180290.1 NZ_CP072902:c1599533-1599138 [Bartonella henselae]
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
Download Length: 396 bp
>AT199145 NZ_CP097214:29103-29321 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829Z6B5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A840E534 |