Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-dinJ/YafQ-RelB |
| Location | 1593554..1594085 | Replicon | chromosome |
| Accession | NZ_CP072902 | ||
| Organism | Bartonella henselae strain ATCC49882T var-2/ Houston-I | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | X5M5T9 |
| Locus tag | KAE74_RS06840 | Protein ID | WP_011180281.1 |
| Coordinates | 1593804..1594085 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | A0A0H3LWD6 |
| Locus tag | KAE74_RS06835 | Protein ID | WP_011180280.1 |
| Coordinates | 1593554..1593817 (+) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE74_RS06810 (KAE74_06660) | 1589700..1589948 | - | 249 | WP_011180274.1 | hypothetical protein | - |
| KAE74_RS06815 (KAE74_06665) | 1589952..1591880 | - | 1929 | WP_011180275.1 | phage terminase large subunit family protein | - |
| KAE74_RS06820 (KAE74_06670) | 1591873..1592454 | - | 582 | WP_011180276.1 | hypothetical protein | - |
| KAE74_RS06825 (KAE74_06675) | 1592517..1592831 | + | 315 | WP_011180277.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE74_RS06830 (KAE74_06680) | 1592848..1593144 | + | 297 | WP_011180278.1 | HigA family addiction module antitoxin | - |
| KAE74_RS06835 (KAE74_06685) | 1593554..1593817 | + | 264 | WP_011180280.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| KAE74_RS06840 (KAE74_06690) | 1593804..1594085 | + | 282 | WP_011180281.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| KAE74_RS06845 (KAE74_06695) | 1594128..1594406 | - | 279 | WP_011180242.1 | hypothetical protein | - |
| KAE74_RS06850 (KAE74_06700) | 1594403..1595161 | - | 759 | WP_011180282.1 | phage antirepressor Ant | - |
| KAE74_RS06855 (KAE74_06705) | 1595221..1595736 | - | 516 | WP_011180283.1 | phage antirepressor Ant | - |
| KAE74_RS06860 (KAE74_06710) | 1595753..1596592 | - | 840 | WP_011180284.1 | antA/AntB antirepressor family protein | - |
| KAE74_RS06865 (KAE74_06715) | 1596624..1597166 | - | 543 | WP_011180285.1 | phage antirepressor Ant | - |
| KAE74_RS06870 (KAE74_06720) | 1597763..1598341 | - | 579 | WP_011180287.1 | hypothetical protein | - |
| KAE74_RS06875 (KAE74_06725) | 1598345..1598665 | - | 321 | WP_011180288.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1551243..1618451 | 67208 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11106.85 Da Isoelectric Point: 10.3380
>T199144 WP_011180281.1 NZ_CP072902:1593804-1594085 [Bartonella henselae]
MRTIERTTIFKRDFKREMKGQHRHLLDTDLRKVIAALANDQPLEIRYRDHALTGNWSNYRDCHIRPDLVLIYRLIGQDRL
VLVRLGSHSQLDL
MRTIERTTIFKRDFKREMKGQHRHLLDTDLRKVIAALANDQPLEIRYRDHALTGNWSNYRDCHIRPDLVLIYRLIGQDRL
VLVRLGSHSQLDL
Download Length: 282 bp
>T199144 NZ_CP097214:28061-28591 [Escherichia coli]
ATGGACGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATGAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTCACCGATCATCTGAAACGTCAGCACAACAGTAAGATTTTACGTGGTTATCTGCTCGTGACGAGAGAGG
ATAAACCACGTGTCATGGGGTACTACACTCTGTCTGGCAGTTGTTTTGAGAAAACACTTCTACCCAGCAAAACACAACAA
AAGCGTGTGCCCTATAAAAATGTTCCTAGTGTGACTTTGGGCCGTCTGGCAATTGATAAAAATCTTCATCGCCAGGGATA
TGGAGAAACACTTGTTACTCATGCTATGAAAGTTGTGTATCAGGCCTCGCAAGCTGTGGGTATACACGGAATGTTCGTGG
AAGCACTGAACGACAACGCCAAAAAGTTCTACCTTCGAATGGGTTTTATACAGTTAAAGGAAGAAAACTGTAATTCGCTC
TTCTACCCGACAAAATCTATTGAAGAATTGTTCGAAGTAAATGATGAATAA
ATGGACGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATGAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTCACCGATCATCTGAAACGTCAGCACAACAGTAAGATTTTACGTGGTTATCTGCTCGTGACGAGAGAGG
ATAAACCACGTGTCATGGGGTACTACACTCTGTCTGGCAGTTGTTTTGAGAAAACACTTCTACCCAGCAAAACACAACAA
AAGCGTGTGCCCTATAAAAATGTTCCTAGTGTGACTTTGGGCCGTCTGGCAATTGATAAAAATCTTCATCGCCAGGGATA
TGGAGAAACACTTGTTACTCATGCTATGAAAGTTGTGTATCAGGCCTCGCAAGCTGTGGGTATACACGGAATGTTCGTGG
AAGCACTGAACGACAACGCCAAAAAGTTCTACCTTCGAATGGGTTTTATACAGTTAAAGGAAGAAAACTGTAATTCGCTC
TTCTACCCGACAAAATCTATTGAAGAATTGTTCGAAGTAAATGATGAATAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9565.81 Da Isoelectric Point: 4.1403
>AT199144 WP_011180280.1 NZ_CP072902:1593554-1593817 [Bartonella henselae]
MATSRMVQARVPEEIQNVASQVIQASGLTVSDVVRVLMTRIAQDKAIPSVLFQPNAETIAAFAEVDEGNLKKFHSVDELF
DDLYADD
MATSRMVQARVPEEIQNVASQVIQASGLTVSDVVRVLMTRIAQDKAIPSVLFQPNAETIAAFAEVDEGNLKKFHSVDELF
DDLYADD
Download Length: 264 bp
>AT199144 NZ_CP097214:27788-28057 [Escherichia coli]
ATGTCAGTACTGAAAAAGCAGCGCATAGATCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCAATCTCACAGTTTATGGTCAGTACCGCTTCAGAACGCGCTGCAGAAGTTATTGATCAGCACCGTCGAC
TGCTCCTTAATGAGGAGTCATGGAACCTGGTTATGGATGCCATCACTAATCCGCCAGTACCAAATGAACGACTGAAACGA
GCCGCTAAACGTCTCCGGGAACTGGAGTAA
ATGTCAGTACTGAAAAAGCAGCGCATAGATCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCAATCTCACAGTTTATGGTCAGTACCGCTTCAGAACGCGCTGCAGAAGTTATTGATCAGCACCGTCGAC
TGCTCCTTAATGAGGAGTCATGGAACCTGGTTATGGATGCCATCACTAATCCGCCAGTACCAAATGAACGACTGAAACGA
GCCGCTAAACGTCTCCGGGAACTGGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0R4J6H3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3LWD6 |