Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-parD/RelE-RHH |
| Location | 264295..264854 | Replicon | chromosome |
| Accession | NZ_CP072902 | ||
| Organism | Bartonella henselae strain ATCC49882T var-2/ Houston-I | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | X5M706 |
| Locus tag | KAE74_RS01255 | Protein ID | WP_011180615.1 |
| Coordinates | 264582..264854 (+) | Length | 91 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | X5LVL8 |
| Locus tag | KAE74_RS01250 | Protein ID | WP_011180616.1 |
| Coordinates | 264295..264585 (+) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE74_RS01205 (KAE74_01190) | 260230..260556 | - | 327 | WP_011180626.1 | hypothetical protein | - |
| KAE74_RS01210 (KAE74_01195) | 260855..261313 | + | 459 | WP_011180624.1 | hypothetical protein | - |
| KAE74_RS01215 | 261409..261801 | + | 393 | WP_075320637.1 | hypothetical protein | - |
| KAE74_RS01220 (KAE74_01200) | 261831..262100 | - | 270 | WP_011180622.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE74_RS01225 (KAE74_01205) | 262084..262311 | - | 228 | WP_007346764.1 | DUF6290 family protein | - |
| KAE74_RS01230 (KAE74_01210) | 262419..262751 | - | 333 | WP_011180620.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| KAE74_RS01235 (KAE74_01215) | 262751..263008 | - | 258 | WP_034448603.1 | antitoxin | - |
| KAE74_RS01240 (KAE74_01220) | 263089..263583 | - | 495 | WP_059443338.1 | hypothetical protein | - |
| KAE74_RS01245 (KAE74_01225) | 263637..264083 | - | 447 | WP_011180617.1 | single-stranded DNA-binding protein | - |
| KAE74_RS01250 (KAE74_01230) | 264295..264585 | + | 291 | WP_011180616.1 | hypothetical protein | Antitoxin |
| KAE74_RS01255 (KAE74_01235) | 264582..264854 | + | 273 | WP_011180615.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| KAE74_RS01260 (KAE74_01240) | 265045..265362 | - | 318 | Protein_242 | hypothetical protein | - |
| KAE74_RS01265 (KAE74_01245) | 265544..265930 | - | 387 | WP_082246570.1 | hypothetical protein | - |
| KAE74_RS01270 (KAE74_01250) | 265914..267164 | - | 1251 | WP_011180612.1 | DUF1376 domain-containing protein | - |
| KAE74_RS01275 (KAE74_01255) | 267154..267633 | - | 480 | WP_011180611.1 | hypothetical protein | - |
| KAE74_RS01280 (KAE74_01260) | 267770..268129 | - | 360 | WP_011180610.1 | hypothetical protein | - |
| KAE74_RS01285 | 268132..268494 | - | 363 | WP_034459412.1 | hypothetical protein | - |
| KAE74_RS01290 (KAE74_01270) | 268579..268917 | + | 339 | WP_011180608.1 | helix-turn-helix transcriptional regulator | - |
| KAE74_RS01295 (KAE74_01275) | 269156..269530 | + | 375 | WP_011180607.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 235926..276048 | 40122 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10747.75 Da Isoelectric Point: 11.3976
>T199141 WP_011180615.1 NZ_CP072902:264582-264854 [Bartonella henselae]
MKLVWTRIAHYDRQKIREYIAQENPSAALVFDKLLSKKVERLISFPNLGRVGRIRNTRELIVRKNYIMIYDVSNGTIRVL
RILHAKQKWP
MKLVWTRIAHYDRQKIREYIAQENPSAALVFDKLLSKKVERLISFPNLGRVGRIRNTRELIVRKNYIMIYDVSNGTIRVL
RILHAKQKWP
Download Length: 273 bp
>T199141 NZ_CP097213:3789192-3789470 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 11099.43 Da Isoelectric Point: 4.5837
>AT199141 WP_011180616.1 NZ_CP072902:264295-264585 [Bartonella henselae]
MAETTFTFRVDDALKSEFSQAAKACDRSAAQLLRDYMRDIVKEQKEKIAHELWFQEQVQLGLNSANAGDVIPFEEIETEA
QAWRFEIQRKLKTSDS
MAETTFTFRVDDALKSEFSQAAKACDRSAAQLLRDYMRDIVKEQKEKIAHELWFQEQVQLGLNSANAGDVIPFEEIETEA
QAWRFEIQRKLKTSDS
Download Length: 291 bp
>AT199141 NZ_CP097213:3788929-3789189 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067W4L5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067W521 |