Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemK-pasA/PRK09812-HTH |
| Location | 262084..262751 | Replicon | chromosome |
| Accession | NZ_CP072902 | ||
| Organism | Bartonella henselae strain ATCC49882T var-2/ Houston-I | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | X5M710 |
| Locus tag | KAE74_RS01230 | Protein ID | WP_011180620.1 |
| Coordinates | 262419..262751 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | N6VJG4 |
| Locus tag | KAE74_RS01225 | Protein ID | WP_007346764.1 |
| Coordinates | 262084..262311 (-) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE74_RS01200 (KAE74_01185) | 258924..260249 | - | 1326 | WP_011180823.1 | phage terminase large subunit | - |
| KAE74_RS01205 (KAE74_01190) | 260230..260556 | - | 327 | WP_011180626.1 | hypothetical protein | - |
| KAE74_RS01210 (KAE74_01195) | 260855..261313 | + | 459 | WP_011180624.1 | hypothetical protein | - |
| KAE74_RS01215 | 261409..261801 | + | 393 | WP_075320637.1 | hypothetical protein | - |
| KAE74_RS01220 (KAE74_01200) | 261831..262100 | - | 270 | WP_011180622.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE74_RS01225 (KAE74_01205) | 262084..262311 | - | 228 | WP_007346764.1 | DUF6290 family protein | Antitoxin |
| KAE74_RS01230 (KAE74_01210) | 262419..262751 | - | 333 | WP_011180620.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| KAE74_RS01235 (KAE74_01215) | 262751..263008 | - | 258 | WP_034448603.1 | antitoxin | - |
| KAE74_RS01240 (KAE74_01220) | 263089..263583 | - | 495 | WP_059443338.1 | hypothetical protein | - |
| KAE74_RS01245 (KAE74_01225) | 263637..264083 | - | 447 | WP_011180617.1 | single-stranded DNA-binding protein | - |
| KAE74_RS01250 (KAE74_01230) | 264295..264585 | + | 291 | WP_011180616.1 | hypothetical protein | - |
| KAE74_RS01255 (KAE74_01235) | 264582..264854 | + | 273 | WP_011180615.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| KAE74_RS01260 (KAE74_01240) | 265045..265362 | - | 318 | Protein_242 | hypothetical protein | - |
| KAE74_RS01265 (KAE74_01245) | 265544..265930 | - | 387 | WP_082246570.1 | hypothetical protein | - |
| KAE74_RS01270 (KAE74_01250) | 265914..267164 | - | 1251 | WP_011180612.1 | DUF1376 domain-containing protein | - |
| KAE74_RS01275 (KAE74_01255) | 267154..267633 | - | 480 | WP_011180611.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 235926..276048 | 40122 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11865.88 Da Isoelectric Point: 10.5590
>T199139 WP_011180620.1 NZ_CP072902:c262751-262419 [Bartonella henselae]
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT
Download Length: 333 bp
>T199139 NZ_CP097213:3506708-3506926 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8742.78 Da Isoelectric Point: 4.8780
>AT199139 WP_007346764.1 NZ_CP072902:c262311-262084 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD
Download Length: 228 bp
>AT199139 NZ_CP097213:3506308-3506682 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067W4K9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | N6VJG4 |